Altered function of pulmonary surfactant in fatty acid lung injury

Stephen (Steve) Hall, R. H. Notter, R. J. Smith, R. W. Hyde

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

To determine whether acute fatty acid lung injury impairs pulmonary surfactant function, we studied anesthetized ventilated rabbits given oleic acid (55 mg/kg iv, n = 11) or an equivalent volume of saline (n = 8). Measurements of pulmonary mechanics indicated a decrease in dynamic compliance within 5 min of injury and a decrease in lung volume that was disproportionately large at low pressures, consistent with diminished surfactant activity in vivo. Bronchoalveolar lavage fluid obtained 1 h after injury had significantly increased erythrocytes and total leukocytes, largely polymorphonuclear cells. The phospholipid content and composition of the cell-free fraction had only minor changes from those of controls, but the protein content was increased 35-fold. Measurements of lavage surface activity in vitro showed an increase in average minimum surface tension from 1.3 ± 0.4 (SE) dyn/cm in controls to 20.2 ± 3.9 dyn/cm in injured animals. The alterations in static pressure-volume curves and decrease in lavage surface activity suggest a severe alteration of surfactant function in this form of lung injury that occurs despite the presence of normal amounts of surfactant phospholipids.

Original languageEnglish (US)
Pages (from-to)1143-1149
Number of pages7
JournalJournal of Applied Physiology
Volume69
Issue number3
StatePublished - 1990
Externally publishedYes

Fingerprint

Pulmonary Surfactants
Lung Injury
Surface-Active Agents
Fatty Acids
Therapeutic Irrigation
Phospholipids
Pressure
Lung
Surface Tension
Bronchoalveolar Lavage Fluid
Wounds and Injuries
Oleic Acid
Mechanics
Compliance
Neutrophils
Erythrocytes
Rabbits
Proteins

Keywords

  • adult respiratory distress syndrome
  • free fatty acid
  • pulmonary edema

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hall, S. S., Notter, R. H., Smith, R. J., & Hyde, R. W. (1990). Altered function of pulmonary surfactant in fatty acid lung injury. Journal of Applied Physiology, 69(3), 1143-1149.

Altered function of pulmonary surfactant in fatty acid lung injury. / Hall, Stephen (Steve); Notter, R. H.; Smith, R. J.; Hyde, R. W.

In: Journal of Applied Physiology, Vol. 69, No. 3, 1990, p. 1143-1149.

Research output: Contribution to journalArticle

Hall, SS, Notter, RH, Smith, RJ & Hyde, RW 1990, 'Altered function of pulmonary surfactant in fatty acid lung injury', Journal of Applied Physiology, vol. 69, no. 3, pp. 1143-1149.
Hall, Stephen (Steve) ; Notter, R. H. ; Smith, R. J. ; Hyde, R. W. / Altered function of pulmonary surfactant in fatty acid lung injury. In: Journal of Applied Physiology. 1990 ; Vol. 69, No. 3. pp. 1143-1149.
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