Altered expression of low affinity insulin-like growth factor binding protein related proteins in hepatoblastoma.

Henrik von Horn, Vivian Hwa, Ron G. Rosenfeld, Kerstin Hall, Bin Tean Teh, Michael Tally, Tomas J. Ekström, Steven G. Gray

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Hepatoblastoma is a poorly understood rare pediatric liver tumour. We have previously shown that the IGF-axis is seriously disrupted in this tumour type. With the recent discovery that several other proteins also have the potential to bind to IGFs called insulin-like growth factor binding protein related proteins (IGFBP-rPs), we undertook an examination of several such genes in a series of hepatoblastomas with matched normal liver tissue. The expression profiles obtained reveal that the expression of these genes are also disturbed in these tumours, and may have implications for our understanding of the IGF-axis and its importance in this disease.

Original languageEnglish (US)
Pages (from-to)645-649
Number of pages5
JournalInternational journal of molecular medicine
Volume9
Issue number6
DOIs
StatePublished - Jun 2002

ASJC Scopus subject areas

  • Genetics

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    von Horn, H., Hwa, V., Rosenfeld, R. G., Hall, K., Teh, B. T., Tally, M., Ekström, T. J., & Gray, S. G. (2002). Altered expression of low affinity insulin-like growth factor binding protein related proteins in hepatoblastoma. International journal of molecular medicine, 9(6), 645-649. https://doi.org/10.3892/ijmm.9.6.645