Abstract
Objective: The authors sought evidence for altered adolescent braingrowthtrajectory associatedwithmoderateand heavy alcohol use in a large national, multisite, prospective study of adolescents before and after initiation of appreciable alcohol use. Method: This study examined 483 adolescents (ages 12-21) before initiation of drinking and 1 and 2 years later. At the 2-year assessment, 356 participants continued to meet the study's no/low alcohol consumption entry criteria, 65 had initiatedmoderate drinking, and 62 had initiated heavy drinking. MRI was used to quantify regional cortical and white matter volumes. Percent change per year (slopes) in adolescents who continued to meet no/low criteria served as developmental control trajectories against which to compare those who initiated moderate or heavy drinking. Results: In no/low drinkers, gray matter volume declined throughout adolescence and slowed in many regions in later adolescence. Complementing gray matter declines, white matter regions grew at faster rates at younger ages and slowed toward young adulthood. Youths who initiated heavy drinking exhibited an accelerated frontal cortical gray matter trajectory, divergent from the norm. Although significant effects on trajectories were not observed in moderate drinkers, their intermediate position between no/lowand heavy drinkers suggests a dose effect. Neithermarijuana co-use nor baseline volumes contributed significantly to the alcohol effect. Conclusions: Initiation of drinking during adolescence, with or without marijuana co-use, disordered normal brain growth trajectories. Factors possibly contributing to abnormal cortical volume trajectories include peak consumption in the past year and family history of alcoholism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 370-380 |
| Number of pages | 11 |
| Journal | American Journal of Psychiatry |
| Volume | 175 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2018 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Altered brain developmental trajectories in adolescents after initiating drinking. / Pfefferbaum, Adolf; Kwon, Dongjin; Brumback, Ty; Thompson, Wesley K.; Cummins, Kevin; Tapert, Susan F.; Brown, Sandra A.; Colrain, Ian M.; Baker, Fiona C.; Prouty, Devin; De Bellis, Michael D.; Clark, Duncan B.; Nagel, Bonnie; Chu, Weiwei; Park, Sang Hyun; Pohl, Kilian M.; Sullivan, Edith V.
In: American Journal of Psychiatry, Vol. 175, No. 4, 01.04.2018, p. 370-380.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered brain developmental trajectories in adolescents after initiating drinking
AU - Pfefferbaum, Adolf
AU - Kwon, Dongjin
AU - Brumback, Ty
AU - Thompson, Wesley K.
AU - Cummins, Kevin
AU - Tapert, Susan F.
AU - Brown, Sandra A.
AU - Colrain, Ian M.
AU - Baker, Fiona C.
AU - Prouty, Devin
AU - De Bellis, Michael D.
AU - Clark, Duncan B.
AU - Nagel, Bonnie
AU - Chu, Weiwei
AU - Park, Sang Hyun
AU - Pohl, Kilian M.
AU - Sullivan, Edith V.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Objective: The authors sought evidence for altered adolescent braingrowthtrajectory associatedwithmoderateand heavy alcohol use in a large national, multisite, prospective study of adolescents before and after initiation of appreciable alcohol use. Method: This study examined 483 adolescents (ages 12-21) before initiation of drinking and 1 and 2 years later. At the 2-year assessment, 356 participants continued to meet the study's no/low alcohol consumption entry criteria, 65 had initiatedmoderate drinking, and 62 had initiated heavy drinking. MRI was used to quantify regional cortical and white matter volumes. Percent change per year (slopes) in adolescents who continued to meet no/low criteria served as developmental control trajectories against which to compare those who initiated moderate or heavy drinking. Results: In no/low drinkers, gray matter volume declined throughout adolescence and slowed in many regions in later adolescence. Complementing gray matter declines, white matter regions grew at faster rates at younger ages and slowed toward young adulthood. Youths who initiated heavy drinking exhibited an accelerated frontal cortical gray matter trajectory, divergent from the norm. Although significant effects on trajectories were not observed in moderate drinkers, their intermediate position between no/lowand heavy drinkers suggests a dose effect. Neithermarijuana co-use nor baseline volumes contributed significantly to the alcohol effect. Conclusions: Initiation of drinking during adolescence, with or without marijuana co-use, disordered normal brain growth trajectories. Factors possibly contributing to abnormal cortical volume trajectories include peak consumption in the past year and family history of alcoholism.
AB - Objective: The authors sought evidence for altered adolescent braingrowthtrajectory associatedwithmoderateand heavy alcohol use in a large national, multisite, prospective study of adolescents before and after initiation of appreciable alcohol use. Method: This study examined 483 adolescents (ages 12-21) before initiation of drinking and 1 and 2 years later. At the 2-year assessment, 356 participants continued to meet the study's no/low alcohol consumption entry criteria, 65 had initiatedmoderate drinking, and 62 had initiated heavy drinking. MRI was used to quantify regional cortical and white matter volumes. Percent change per year (slopes) in adolescents who continued to meet no/low criteria served as developmental control trajectories against which to compare those who initiated moderate or heavy drinking. Results: In no/low drinkers, gray matter volume declined throughout adolescence and slowed in many regions in later adolescence. Complementing gray matter declines, white matter regions grew at faster rates at younger ages and slowed toward young adulthood. Youths who initiated heavy drinking exhibited an accelerated frontal cortical gray matter trajectory, divergent from the norm. Although significant effects on trajectories were not observed in moderate drinkers, their intermediate position between no/lowand heavy drinkers suggests a dose effect. Neithermarijuana co-use nor baseline volumes contributed significantly to the alcohol effect. Conclusions: Initiation of drinking during adolescence, with or without marijuana co-use, disordered normal brain growth trajectories. Factors possibly contributing to abnormal cortical volume trajectories include peak consumption in the past year and family history of alcoholism.
UR - http://www.scopus.com/inward/record.url?scp=85044824796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044824796&partnerID=8YFLogxK
U2 - 10.1176/appi.ajp.2017.17040469
DO - 10.1176/appi.ajp.2017.17040469
M3 - Article
C2 - 29084454
AN - SCOPUS:85044824796
VL - 175
SP - 370
EP - 380
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 4
ER -