Abstract
To investigate the physiology of noise-induced hearing loss, the sound-induced vibrations of the basilar membrane (BM) of the inner ear were measured in living anesthetized guinea pigs before and after intense sound exposure. The vibrations were measured using a laser Doppler velocimeter after placing reflective glass beads on the BM. Pseudo-random noise waveforms containing frequencies between 4 and 24 kHz were used to generate velocity tuning curves. Before overstimulation, sharp response peaks were seen at stimulus frequencies between 15 and 17 kHz, consistent with the expected best frequency of the recording location. The response to low level stimuli lagged the high level ones by up to 90° at the characteristic frequency. Following exposure to loud sound, the BM vibrations showed a pronounced reduction in amplitude, primarily at low stimulus levels, and the best frequency moved to approximately 12 kHz. At higher levels, the reduction was either absent or much smaller. In addition to the amplitude changes, increased phase lags were seen at frequencies near the characteristic frequency. In animals with more severe exposures, response phases were altered also at frequencies showing no change of the amplitude. The phase was independent of stimulus level after severe exposures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 214-222 |
| Number of pages | 9 |
| Journal | Hearing Research |
| Volume | 167 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 2002 |
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Keywords
- Basilar membrane
- Guinea pig
- Laser velocimetry
- Noise-induced hearing loss
- Response phase
ASJC Scopus subject areas
- Sensory Systems
Cite this
Alterations of basilar membrane response phase and velocity after acoustic overstimulation. / Fridberger, Anders; Zheng, Jiefu; Nuttall, Alfred.
In: Hearing Research, Vol. 167, No. 1-2, 2002, p. 214-222.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alterations of basilar membrane response phase and velocity after acoustic overstimulation
AU - Fridberger, Anders
AU - Zheng, Jiefu
AU - Nuttall, Alfred
PY - 2002
Y1 - 2002
N2 - To investigate the physiology of noise-induced hearing loss, the sound-induced vibrations of the basilar membrane (BM) of the inner ear were measured in living anesthetized guinea pigs before and after intense sound exposure. The vibrations were measured using a laser Doppler velocimeter after placing reflective glass beads on the BM. Pseudo-random noise waveforms containing frequencies between 4 and 24 kHz were used to generate velocity tuning curves. Before overstimulation, sharp response peaks were seen at stimulus frequencies between 15 and 17 kHz, consistent with the expected best frequency of the recording location. The response to low level stimuli lagged the high level ones by up to 90° at the characteristic frequency. Following exposure to loud sound, the BM vibrations showed a pronounced reduction in amplitude, primarily at low stimulus levels, and the best frequency moved to approximately 12 kHz. At higher levels, the reduction was either absent or much smaller. In addition to the amplitude changes, increased phase lags were seen at frequencies near the characteristic frequency. In animals with more severe exposures, response phases were altered also at frequencies showing no change of the amplitude. The phase was independent of stimulus level after severe exposures.
AB - To investigate the physiology of noise-induced hearing loss, the sound-induced vibrations of the basilar membrane (BM) of the inner ear were measured in living anesthetized guinea pigs before and after intense sound exposure. The vibrations were measured using a laser Doppler velocimeter after placing reflective glass beads on the BM. Pseudo-random noise waveforms containing frequencies between 4 and 24 kHz were used to generate velocity tuning curves. Before overstimulation, sharp response peaks were seen at stimulus frequencies between 15 and 17 kHz, consistent with the expected best frequency of the recording location. The response to low level stimuli lagged the high level ones by up to 90° at the characteristic frequency. Following exposure to loud sound, the BM vibrations showed a pronounced reduction in amplitude, primarily at low stimulus levels, and the best frequency moved to approximately 12 kHz. At higher levels, the reduction was either absent or much smaller. In addition to the amplitude changes, increased phase lags were seen at frequencies near the characteristic frequency. In animals with more severe exposures, response phases were altered also at frequencies showing no change of the amplitude. The phase was independent of stimulus level after severe exposures.
KW - Basilar membrane
KW - Guinea pig
KW - Laser velocimetry
KW - Noise-induced hearing loss
KW - Response phase
UR - http://www.scopus.com/inward/record.url?scp=0036020120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036020120&partnerID=8YFLogxK
U2 - 10.1016/S0378-5955(02)00396-9
DO - 10.1016/S0378-5955(02)00396-9
M3 - Article
C2 - 12117544
AN - SCOPUS:0036020120
VL - 167
SP - 214
EP - 222
JO - Hearing Research
JF - Hearing Research
SN - 0378-5955
IS - 1-2
ER -