Abstract
The oxygen tension (pO2) of endolymph of the guinea pig cochlea was measured during exposure to loud sound (12 kHz or high-pass noise; 110 dB SPL up to 1h duration). A small, but significant, steady decline in mean pO2 was observed after both pure tone and high-pass noise exposure. The extent of the change in pO2 varied from 0-50% in individual animals. compared with unexposed control animals. All exposed animals had an extensive loss of compound action potential (CAP) thresholds at frequencies of 8-30 kHz. However, there was no relationship between the extent of the change in pO2 of endolymph and CAP threshold loss.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 71-79 |
| Number of pages | 9 |
| Journal | Acta Oto-Laryngologica |
| Volume | 107 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 1989 |
| Externally published | Yes |
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Keywords
- Acoustic trauma
- Endolymph
- Oxygen microelectrode
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Alterations in oxygenation of cochlear endolymph during loud sound exposure. / Thorne, P. R.; Nuttall, Alfred.
In: Acta Oto-Laryngologica, Vol. 107, No. 1-2, 1989, p. 71-79.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alterations in oxygenation of cochlear endolymph during loud sound exposure
AU - Thorne, P. R.
AU - Nuttall, Alfred
PY - 1989
Y1 - 1989
N2 - The oxygen tension (pO2) of endolymph of the guinea pig cochlea was measured during exposure to loud sound (12 kHz or high-pass noise; 110 dB SPL up to 1h duration). A small, but significant, steady decline in mean pO2 was observed after both pure tone and high-pass noise exposure. The extent of the change in pO2 varied from 0-50% in individual animals. compared with unexposed control animals. All exposed animals had an extensive loss of compound action potential (CAP) thresholds at frequencies of 8-30 kHz. However, there was no relationship between the extent of the change in pO2 of endolymph and CAP threshold loss.
AB - The oxygen tension (pO2) of endolymph of the guinea pig cochlea was measured during exposure to loud sound (12 kHz or high-pass noise; 110 dB SPL up to 1h duration). A small, but significant, steady decline in mean pO2 was observed after both pure tone and high-pass noise exposure. The extent of the change in pO2 varied from 0-50% in individual animals. compared with unexposed control animals. All exposed animals had an extensive loss of compound action potential (CAP) thresholds at frequencies of 8-30 kHz. However, there was no relationship between the extent of the change in pO2 of endolymph and CAP threshold loss.
KW - Acoustic trauma
KW - Endolymph
KW - Oxygen microelectrode
UR - http://www.scopus.com/inward/record.url?scp=0024499857&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024499857&partnerID=8YFLogxK
U2 - 10.3109/00016488909127481
DO - 10.3109/00016488909127481
M3 - Article
VL - 107
SP - 71
EP - 79
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
SN - 0001-6489
IS - 1-2
ER -