Alterations in oxygenation of cochlear endolymph during loud sound exposure

P. R. Thorne; A. L. Nuttall

doi:10.3109/00016488909127481

Alterations in oxygenation of cochlear endolymph during loud sound exposure

P. R. Thorne, A. L. Nuttall

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The oxygen tension (pO₂) of endolymph of the guinea pig cochlea was measured during exposure to loud sound (12 kHz or high-pass noise; 110 dB SPL up to 1h duration). A small, but significant, steady decline in mean pO₂ was observed after both pure tone and high-pass noise exposure. The extent of the change in pO₂ varied from 0-50% in individual animals. compared with unexposed control animals. All exposed animals had an extensive loss of compound action potential (CAP) thresholds at frequencies of 8-30 kHz. However, there was no relationship between the extent of the change in pO₂ of endolymph and CAP threshold loss.

Original language	English (US)
Pages (from-to)	71-79
Number of pages	9
Journal	Acta Oto-Laryngologica
Volume	107
Issue number	1-2
DOIs	https://doi.org/10.3109/00016488909127481
State	Published - 1989
Externally published	Yes

Keywords

Acoustic trauma
Endolymph
Oxygen microelectrode

ASJC Scopus subject areas

Otorhinolaryngology

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10.3109/00016488909127481

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@article{af91e4e45df34b93b109cab80b77fa22,

title = "Alterations in oxygenation of cochlear endolymph during loud sound exposure",

abstract = "The oxygen tension (pO2) of endolymph of the guinea pig cochlea was measured during exposure to loud sound (12 kHz or high-pass noise; 110 dB SPL up to 1h duration). A small, but significant, steady decline in mean pO2 was observed after both pure tone and high-pass noise exposure. The extent of the change in pO2 varied from 0-50% in individual animals. compared with unexposed control animals. All exposed animals had an extensive loss of compound action potential (CAP) thresholds at frequencies of 8-30 kHz. However, there was no relationship between the extent of the change in pO2 of endolymph and CAP threshold loss.",

keywords = "Acoustic trauma, Endolymph, Oxygen microelectrode",

author = "Thorne, {P. R.} and Nuttall, {A. L.}",

note = "Funding Information: The authors would like to thank J. N. Brown, M. Griffiths andT. E. Billett for technical assistance, and J. Hardy and S. E. Oakden for help in preparing the manuscript. We acknowledge the gift of fentanyl from Janssen Pharmaceuticals Ltd. This research was supported by USPHS International Research Fellowship No. TWO. 3473 and a grant from the Deafness Research Foundation of New Zealand to P. R. Thome, and NIH Grant 11731 to A. L. Nuttall.",

year = "1989",

doi = "10.3109/00016488909127481",

language = "English (US)",

volume = "107",

pages = "71--79",

journal = "Acta Oto-Laryngologica",

issn = "0001-6489",

publisher = "Informa Healthcare",

number = "1-2",

}

TY - JOUR

T1 - Alterations in oxygenation of cochlear endolymph during loud sound exposure

AU - Thorne, P. R.

AU - Nuttall, A. L.

N1 - Funding Information: The authors would like to thank J. N. Brown, M. Griffiths andT. E. Billett for technical assistance, and J. Hardy and S. E. Oakden for help in preparing the manuscript. We acknowledge the gift of fentanyl from Janssen Pharmaceuticals Ltd. This research was supported by USPHS International Research Fellowship No. TWO. 3473 and a grant from the Deafness Research Foundation of New Zealand to P. R. Thome, and NIH Grant 11731 to A. L. Nuttall.

PY - 1989

Y1 - 1989

N2 - The oxygen tension (pO2) of endolymph of the guinea pig cochlea was measured during exposure to loud sound (12 kHz or high-pass noise; 110 dB SPL up to 1h duration). A small, but significant, steady decline in mean pO2 was observed after both pure tone and high-pass noise exposure. The extent of the change in pO2 varied from 0-50% in individual animals. compared with unexposed control animals. All exposed animals had an extensive loss of compound action potential (CAP) thresholds at frequencies of 8-30 kHz. However, there was no relationship between the extent of the change in pO2 of endolymph and CAP threshold loss.

AB - The oxygen tension (pO2) of endolymph of the guinea pig cochlea was measured during exposure to loud sound (12 kHz or high-pass noise; 110 dB SPL up to 1h duration). A small, but significant, steady decline in mean pO2 was observed after both pure tone and high-pass noise exposure. The extent of the change in pO2 varied from 0-50% in individual animals. compared with unexposed control animals. All exposed animals had an extensive loss of compound action potential (CAP) thresholds at frequencies of 8-30 kHz. However, there was no relationship between the extent of the change in pO2 of endolymph and CAP threshold loss.

KW - Acoustic trauma

KW - Endolymph

KW - Oxygen microelectrode

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JO - Acta Oto-Laryngologica

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SN - 0001-6489

IS - 1-2

ER -

Alterations in oxygenation of cochlear endolymph during loud sound exposure

Abstract

Keywords

ASJC Scopus subject areas

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