Alterations in oxygenation of cochlear endolymph during loud sound exposure

P. R. Thorne, A. L. Nuttall

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The oxygen tension (pO2) of endolymph of the guinea pig cochlea was measured during exposure to loud sound (12 kHz or high-pass noise; 110 dB SPL up to 1h duration). A small, but significant, steady decline in mean pO2 was observed after both pure tone and high-pass noise exposure. The extent of the change in pO2 varied from 0-50% in individual animals. compared with unexposed control animals. All exposed animals had an extensive loss of compound action potential (CAP) thresholds at frequencies of 8-30 kHz. However, there was no relationship between the extent of the change in pO2 of endolymph and CAP threshold loss.

Original languageEnglish (US)
Pages (from-to)71-79
Number of pages9
JournalActa Oto-Laryngologica
Issue number1-2
StatePublished - 1989
Externally publishedYes


  • Acoustic trauma
  • Endolymph
  • Oxygen microelectrode

ASJC Scopus subject areas

  • Otorhinolaryngology


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