Alterations in left ventricular torsion and diastolic recoil after myocardial infarction with and without chronic ischemic mitral regurgitation

Frederick (Fred) Tibayan, Filiberto Rodriguez, Frank Langer, Mary K. Zasio, Lynn Bailey, David Liang, George T. Daughters, Neil B. Ingels, D. Craig Miller

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background-Chronic ischemic mitral regurgitation (CIMR) is associated with heart failure that continues unabated whether the valve is repaired, replaced, or ignored. Altered left ventricular (LV) torsion dynamics, with deleterious effects on transmural gradients of oxygen consumption and diastolic filling, may play a role in the cycle of the failing myocardium. We hypothesized that LV dilatation and perturbations in torsion would be greater in animals in which CIMR developed after inferior myocardial infarction (MI) than in those that it did not. Methods-8±2 days after marker placement in sheep, 3-dimensional fluoroscopic marker data (baseline) were obtained before creating inferior MI by snare occlusion. After 7±1 weeks, the animals were restudied (chronic). Inferior MI resulted in CIMR in 11 animals but not in 9 (non-CIMR). End-diastolic septal-lateral and anterior-posterior LV diameters, maximal torsional deformation (φmax, rotation of the LV apex with respect to the base), and torsional recoil in early diastole (φ5%, first 5% of filling) for each LV free wall region (anterior, lateral, posterior) were measured. Results-Both CIMR and non-CIMR animals demonstrated derangement of LV torsion after inferior MI. In contrast to non-CIMR, CIMR animals exhibited greater LV dilation and significant reductions in posterior maximal torsion (6.1±4.3° to 3.9±1.9°* to versus 4.4±2.5° to 2.8±2.0°; mean±SD, baseline to chronic, *P

Original languageEnglish (US)
JournalCirculation
Volume110
Issue number11 SUPPL.
DOIs
StatePublished - Sep 14 2004
Externally publishedYes

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Mitral Valve Insufficiency
Myocardial Infarction
Inferior Wall Myocardial Infarction
Dilatation
Diastole
Oxygen Consumption
Sheep
Myocardium
Heart Failure

Keywords

  • Mechanics
  • Mitral valve
  • Myocardial infarction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Alterations in left ventricular torsion and diastolic recoil after myocardial infarction with and without chronic ischemic mitral regurgitation. / Tibayan, Frederick (Fred); Rodriguez, Filiberto; Langer, Frank; Zasio, Mary K.; Bailey, Lynn; Liang, David; Daughters, George T.; Ingels, Neil B.; Miller, D. Craig.

In: Circulation, Vol. 110, No. 11 SUPPL., 14.09.2004.

Research output: Contribution to journalArticle

Tibayan, Frederick (Fred) ; Rodriguez, Filiberto ; Langer, Frank ; Zasio, Mary K. ; Bailey, Lynn ; Liang, David ; Daughters, George T. ; Ingels, Neil B. ; Miller, D. Craig. / Alterations in left ventricular torsion and diastolic recoil after myocardial infarction with and without chronic ischemic mitral regurgitation. In: Circulation. 2004 ; Vol. 110, No. 11 SUPPL.
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AU - Rodriguez, Filiberto

AU - Langer, Frank

AU - Zasio, Mary K.

AU - Bailey, Lynn

AU - Liang, David

AU - Daughters, George T.

AU - Ingels, Neil B.

AU - Miller, D. Craig

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N2 - Background-Chronic ischemic mitral regurgitation (CIMR) is associated with heart failure that continues unabated whether the valve is repaired, replaced, or ignored. Altered left ventricular (LV) torsion dynamics, with deleterious effects on transmural gradients of oxygen consumption and diastolic filling, may play a role in the cycle of the failing myocardium. We hypothesized that LV dilatation and perturbations in torsion would be greater in animals in which CIMR developed after inferior myocardial infarction (MI) than in those that it did not. Methods-8±2 days after marker placement in sheep, 3-dimensional fluoroscopic marker data (baseline) were obtained before creating inferior MI by snare occlusion. After 7±1 weeks, the animals were restudied (chronic). Inferior MI resulted in CIMR in 11 animals but not in 9 (non-CIMR). End-diastolic septal-lateral and anterior-posterior LV diameters, maximal torsional deformation (φmax, rotation of the LV apex with respect to the base), and torsional recoil in early diastole (φ5%, first 5% of filling) for each LV free wall region (anterior, lateral, posterior) were measured. Results-Both CIMR and non-CIMR animals demonstrated derangement of LV torsion after inferior MI. In contrast to non-CIMR, CIMR animals exhibited greater LV dilation and significant reductions in posterior maximal torsion (6.1±4.3° to 3.9±1.9°* to versus 4.4±2.5° to 2.8±2.0°; mean±SD, baseline to chronic, *P

AB - Background-Chronic ischemic mitral regurgitation (CIMR) is associated with heart failure that continues unabated whether the valve is repaired, replaced, or ignored. Altered left ventricular (LV) torsion dynamics, with deleterious effects on transmural gradients of oxygen consumption and diastolic filling, may play a role in the cycle of the failing myocardium. We hypothesized that LV dilatation and perturbations in torsion would be greater in animals in which CIMR developed after inferior myocardial infarction (MI) than in those that it did not. Methods-8±2 days after marker placement in sheep, 3-dimensional fluoroscopic marker data (baseline) were obtained before creating inferior MI by snare occlusion. After 7±1 weeks, the animals were restudied (chronic). Inferior MI resulted in CIMR in 11 animals but not in 9 (non-CIMR). End-diastolic septal-lateral and anterior-posterior LV diameters, maximal torsional deformation (φmax, rotation of the LV apex with respect to the base), and torsional recoil in early diastole (φ5%, first 5% of filling) for each LV free wall region (anterior, lateral, posterior) were measured. Results-Both CIMR and non-CIMR animals demonstrated derangement of LV torsion after inferior MI. In contrast to non-CIMR, CIMR animals exhibited greater LV dilation and significant reductions in posterior maximal torsion (6.1±4.3° to 3.9±1.9°* to versus 4.4±2.5° to 2.8±2.0°; mean±SD, baseline to chronic, *P

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