Alterations in left ventricular curvature and principal strains dilated cardiomyopathy with functional mitral regurgitation

Frederick (Fred) Tibayan, David T M Lai, Tomasz A. Timek, Paul Dagum, David Liang, Mary K. Zasio, George T. Daughters, D. Craig Miller, Neil B. Ingels

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background and aim of the study: Functional mitral regurgitation (FMR) is increasingly recognized as a left ventricular (LV) disease. Dilated cardiomyopathy (DCM) is commonly accompanied by FMR and reduction of LV torsion. Therapeutic targets for DCM include LV size reduction, altered LV shape, elimination of MR, and increasing LV torsion. It was hypothesized that, in addition to increasing LV size, DCM with FMR would alter normal LV shape and reduce and alter the direction of principal strains across the LV wall. This hypothesis was tested by measuring changes in epicardial and endocardial 2-D principal strains and regional radii of curvature accompanying tachycardia-induced cardiomyopathy in ovine hearts. Methods: Radio-opaque marker arrays were implanted into the left ventricle of eight sheep, including one subepicardial triangle and one subendocardial triangle in the anterior wall of the left ventricle. At one week postoperatively, biplane videofluoscopy was used to determine marker dynamics. Rapid ventricular pacing was then instituted until FMR and signs of heart failure developed, and fluoroscopy was repeated. Circumferential LV radii of curvature were determined from marker triplets. Results: DCM changed the normal epicardial oval LV cross-section to a more circular configuration. The endocardium maintained its normal circular shape as the left ventricle dilated. Deformations of the triangles from end-diastole to end-systole were determined, and the magnitude and direction of 2-D principal strains calculated. DCM was associated with decreased magnitude of both epicardial (-0.095 ± 0.055 versus -0.040 ± 0.032, p = 0.006) and endocardial (-0.117 ± 0.047 versus -0.073 ± 0.037, p = 0.023) principal strains. DCM reduced the angle of epicardial but not endocardial principal strain. Conclusion: DCM with FMR is associated with LV dilation, circularization of the normally oval equatorial circumferential LV epicardium, transmural reduction in principal strain, and decrease in angle of principal epicardial strain. These changes contribute to a reduction in the net torsional moment and may guide the development of reverse remodeling procedures for the dilated, failing ventricle with, FMR.

Original languageEnglish (US)
Pages (from-to)292-299
Number of pages8
JournalJournal of Heart Valve Disease
Volume12
Issue number3
StatePublished - May 2003
Externally publishedYes

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Dilated Cardiomyopathy
Mitral Valve Insufficiency
Heart Ventricles
Sheep
Endocardium
Diastole
Systole
Pericardium
Fluoroscopy
Cardiomyopathies
Tachycardia
Dilatation
Heart Failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Tibayan, F. F., Lai, D. T. M., Timek, T. A., Dagum, P., Liang, D., Zasio, M. K., ... Ingels, N. B. (2003). Alterations in left ventricular curvature and principal strains dilated cardiomyopathy with functional mitral regurgitation. Journal of Heart Valve Disease, 12(3), 292-299.

Alterations in left ventricular curvature and principal strains dilated cardiomyopathy with functional mitral regurgitation. / Tibayan, Frederick (Fred); Lai, David T M; Timek, Tomasz A.; Dagum, Paul; Liang, David; Zasio, Mary K.; Daughters, George T.; Miller, D. Craig; Ingels, Neil B.

In: Journal of Heart Valve Disease, Vol. 12, No. 3, 05.2003, p. 292-299.

Research output: Contribution to journalArticle

Tibayan, FF, Lai, DTM, Timek, TA, Dagum, P, Liang, D, Zasio, MK, Daughters, GT, Miller, DC & Ingels, NB 2003, 'Alterations in left ventricular curvature and principal strains dilated cardiomyopathy with functional mitral regurgitation', Journal of Heart Valve Disease, vol. 12, no. 3, pp. 292-299.
Tibayan, Frederick (Fred) ; Lai, David T M ; Timek, Tomasz A. ; Dagum, Paul ; Liang, David ; Zasio, Mary K. ; Daughters, George T. ; Miller, D. Craig ; Ingels, Neil B. / Alterations in left ventricular curvature and principal strains dilated cardiomyopathy with functional mitral regurgitation. In: Journal of Heart Valve Disease. 2003 ; Vol. 12, No. 3. pp. 292-299.
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abstract = "Background and aim of the study: Functional mitral regurgitation (FMR) is increasingly recognized as a left ventricular (LV) disease. Dilated cardiomyopathy (DCM) is commonly accompanied by FMR and reduction of LV torsion. Therapeutic targets for DCM include LV size reduction, altered LV shape, elimination of MR, and increasing LV torsion. It was hypothesized that, in addition to increasing LV size, DCM with FMR would alter normal LV shape and reduce and alter the direction of principal strains across the LV wall. This hypothesis was tested by measuring changes in epicardial and endocardial 2-D principal strains and regional radii of curvature accompanying tachycardia-induced cardiomyopathy in ovine hearts. Methods: Radio-opaque marker arrays were implanted into the left ventricle of eight sheep, including one subepicardial triangle and one subendocardial triangle in the anterior wall of the left ventricle. At one week postoperatively, biplane videofluoscopy was used to determine marker dynamics. Rapid ventricular pacing was then instituted until FMR and signs of heart failure developed, and fluoroscopy was repeated. Circumferential LV radii of curvature were determined from marker triplets. Results: DCM changed the normal epicardial oval LV cross-section to a more circular configuration. The endocardium maintained its normal circular shape as the left ventricle dilated. Deformations of the triangles from end-diastole to end-systole were determined, and the magnitude and direction of 2-D principal strains calculated. DCM was associated with decreased magnitude of both epicardial (-0.095 ± 0.055 versus -0.040 ± 0.032, p = 0.006) and endocardial (-0.117 ± 0.047 versus -0.073 ± 0.037, p = 0.023) principal strains. DCM reduced the angle of epicardial but not endocardial principal strain. Conclusion: DCM with FMR is associated with LV dilation, circularization of the normally oval equatorial circumferential LV epicardium, transmural reduction in principal strain, and decrease in angle of principal epicardial strain. These changes contribute to a reduction in the net torsional moment and may guide the development of reverse remodeling procedures for the dilated, failing ventricle with, FMR.",
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T1 - Alterations in left ventricular curvature and principal strains dilated cardiomyopathy with functional mitral regurgitation

AU - Tibayan, Frederick (Fred)

AU - Lai, David T M

AU - Timek, Tomasz A.

AU - Dagum, Paul

AU - Liang, David

AU - Zasio, Mary K.

AU - Daughters, George T.

AU - Miller, D. Craig

AU - Ingels, Neil B.

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N2 - Background and aim of the study: Functional mitral regurgitation (FMR) is increasingly recognized as a left ventricular (LV) disease. Dilated cardiomyopathy (DCM) is commonly accompanied by FMR and reduction of LV torsion. Therapeutic targets for DCM include LV size reduction, altered LV shape, elimination of MR, and increasing LV torsion. It was hypothesized that, in addition to increasing LV size, DCM with FMR would alter normal LV shape and reduce and alter the direction of principal strains across the LV wall. This hypothesis was tested by measuring changes in epicardial and endocardial 2-D principal strains and regional radii of curvature accompanying tachycardia-induced cardiomyopathy in ovine hearts. Methods: Radio-opaque marker arrays were implanted into the left ventricle of eight sheep, including one subepicardial triangle and one subendocardial triangle in the anterior wall of the left ventricle. At one week postoperatively, biplane videofluoscopy was used to determine marker dynamics. Rapid ventricular pacing was then instituted until FMR and signs of heart failure developed, and fluoroscopy was repeated. Circumferential LV radii of curvature were determined from marker triplets. Results: DCM changed the normal epicardial oval LV cross-section to a more circular configuration. The endocardium maintained its normal circular shape as the left ventricle dilated. Deformations of the triangles from end-diastole to end-systole were determined, and the magnitude and direction of 2-D principal strains calculated. DCM was associated with decreased magnitude of both epicardial (-0.095 ± 0.055 versus -0.040 ± 0.032, p = 0.006) and endocardial (-0.117 ± 0.047 versus -0.073 ± 0.037, p = 0.023) principal strains. DCM reduced the angle of epicardial but not endocardial principal strain. Conclusion: DCM with FMR is associated with LV dilation, circularization of the normally oval equatorial circumferential LV epicardium, transmural reduction in principal strain, and decrease in angle of principal epicardial strain. These changes contribute to a reduction in the net torsional moment and may guide the development of reverse remodeling procedures for the dilated, failing ventricle with, FMR.

AB - Background and aim of the study: Functional mitral regurgitation (FMR) is increasingly recognized as a left ventricular (LV) disease. Dilated cardiomyopathy (DCM) is commonly accompanied by FMR and reduction of LV torsion. Therapeutic targets for DCM include LV size reduction, altered LV shape, elimination of MR, and increasing LV torsion. It was hypothesized that, in addition to increasing LV size, DCM with FMR would alter normal LV shape and reduce and alter the direction of principal strains across the LV wall. This hypothesis was tested by measuring changes in epicardial and endocardial 2-D principal strains and regional radii of curvature accompanying tachycardia-induced cardiomyopathy in ovine hearts. Methods: Radio-opaque marker arrays were implanted into the left ventricle of eight sheep, including one subepicardial triangle and one subendocardial triangle in the anterior wall of the left ventricle. At one week postoperatively, biplane videofluoscopy was used to determine marker dynamics. Rapid ventricular pacing was then instituted until FMR and signs of heart failure developed, and fluoroscopy was repeated. Circumferential LV radii of curvature were determined from marker triplets. Results: DCM changed the normal epicardial oval LV cross-section to a more circular configuration. The endocardium maintained its normal circular shape as the left ventricle dilated. Deformations of the triangles from end-diastole to end-systole were determined, and the magnitude and direction of 2-D principal strains calculated. DCM was associated with decreased magnitude of both epicardial (-0.095 ± 0.055 versus -0.040 ± 0.032, p = 0.006) and endocardial (-0.117 ± 0.047 versus -0.073 ± 0.037, p = 0.023) principal strains. DCM reduced the angle of epicardial but not endocardial principal strain. Conclusion: DCM with FMR is associated with LV dilation, circularization of the normally oval equatorial circumferential LV epicardium, transmural reduction in principal strain, and decrease in angle of principal epicardial strain. These changes contribute to a reduction in the net torsional moment and may guide the development of reverse remodeling procedures for the dilated, failing ventricle with, FMR.

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