Alteration of T‐Lymphocyte Subpopulations in Children, Youth and Adults with Hemophilia A

L. J. Wolff, M. Borzy, M. Kamoun, E. W. Lovrien

Research output: Contribution to journalArticlepeer-review

Abstract

Thymic processed lymphocytes subpopulations were assayed in 32 healthy patients with hemophilia A and no inhibitor. Commercial concentrates were infused at various frequencies. Monoclonal antibodies to OKT3, OKT4 and OKT8 were measured and compared to age controls. A progressive decrease in percent OKT4 cells, a progressive increase in percent OKT8 cells and gradual decline in the T4/T8 ratio were noted with increase in the patients' age. A correlation between the amount of concentrate received and alteration in T cell subsets was observed in 4 children only. These early and progressive alterations in the T‐lymphocyte subsets suggest early immunocompromise and warrant close patient surveillance and immunologic scrutiny.

Original languageEnglish (US)
Pages (from-to)375-377
Number of pages3
JournalScandinavian Journal of Haematology
Volume33
Issue number40 S
DOIs
StatePublished - Dec 1984

Keywords

  • AIDS
  • Hemophilia A
  • T‐lymphocyte subsets

ASJC Scopus subject areas

  • Hematology

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