Alteration of ascending thoracic aorta compliance after treatment with menotropin

R. Chelsky, R. A. Wilson, M. J. Morton, K. A. Burry, Phillip Patton, J. Szumowski, George Giraud, M. E T Quigley, S. R. Henderson, J. T. Parer

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE: Our purpose was to determine whether aortic size and compliance are altered by an exogenously induced rise in estrogen. STUDY DESIGN: Magnetic resonance imaging was used to determine the aortic cross- sectional area/aortic pressure relationship in nine premenopausal women before and after menotropin therapy. Simultaneous electrocardiograms, carotid pulse tracings, phonocardiograms, and brachial artery pressures were obtained before each magnetic resonance imaging acquisition. Ascending thoracic aorta cross-sectional area was obtained every 32 msec and aligned with brachial artery pressures extrapolated from the carotid pulse tracing, allowing construction of the ascending thoracic aorta cross-sectional area/aortic pressure relationships. Aortic cross-sectional area was normalized to body surface area, and the shifts in the position for the ascending thoracic aorta cross-sectional area/aortic pressure relationship were determined with use of analysis of covariance. RESULTS: Heart rate and aortic pressure were unchanged before and after menotropin treatment. Initial estradiol levels were 2/m2 before and 403 ± 7 mm2/m2 after menotropin treatment (p <0.24). The slope of the ascending aorta cross-sectional area/aortic pressure relationship, an index of aortic compliance, increased from 1.4 ± 0.6 mm2/m2/mm Hg before to 1.7 ± 0.6 mm2/m2/mm Hg after menotropin treatment (p <0.001). CONCLUSION: In premenopausal women a short- term rise in estrogen induced by menotropin treatment is associated with an increase in aortic compliance. Aorta size is not significantly increased within this time frame.

Original languageEnglish (US)
Pages (from-to)1255-1261
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume176
Issue number6
DOIs
StatePublished - 1997

Fingerprint

Menotropins
Thoracic Aorta
Compliance
Aorta
Arterial Pressure
Brachial Artery
Pulse
Estrogens
Magnetic Resonance Imaging
Therapeutics
Pressure
Body Surface Area
Estradiol
Electrocardiography
Heart Rate

Keywords

  • Aorta
  • Aortic compliance
  • Estrogen
  • Menotropins

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Alteration of ascending thoracic aorta compliance after treatment with menotropin. / Chelsky, R.; Wilson, R. A.; Morton, M. J.; Burry, K. A.; Patton, Phillip; Szumowski, J.; Giraud, George; Quigley, M. E T; Henderson, S. R.; Parer, J. T.

In: American Journal of Obstetrics and Gynecology, Vol. 176, No. 6, 1997, p. 1255-1261.

Research output: Contribution to journalArticle

Chelsky, R, Wilson, RA, Morton, MJ, Burry, KA, Patton, P, Szumowski, J, Giraud, G, Quigley, MET, Henderson, SR & Parer, JT 1997, 'Alteration of ascending thoracic aorta compliance after treatment with menotropin', American Journal of Obstetrics and Gynecology, vol. 176, no. 6, pp. 1255-1261. https://doi.org/10.1016/S0002-9378(97)70343-0
Chelsky, R. ; Wilson, R. A. ; Morton, M. J. ; Burry, K. A. ; Patton, Phillip ; Szumowski, J. ; Giraud, George ; Quigley, M. E T ; Henderson, S. R. ; Parer, J. T. / Alteration of ascending thoracic aorta compliance after treatment with menotropin. In: American Journal of Obstetrics and Gynecology. 1997 ; Vol. 176, No. 6. pp. 1255-1261.
@article{1f2e6e1a0dcd4b6097de8553788e23e0,
title = "Alteration of ascending thoracic aorta compliance after treatment with menotropin",
abstract = "OBJECTIVE: Our purpose was to determine whether aortic size and compliance are altered by an exogenously induced rise in estrogen. STUDY DESIGN: Magnetic resonance imaging was used to determine the aortic cross- sectional area/aortic pressure relationship in nine premenopausal women before and after menotropin therapy. Simultaneous electrocardiograms, carotid pulse tracings, phonocardiograms, and brachial artery pressures were obtained before each magnetic resonance imaging acquisition. Ascending thoracic aorta cross-sectional area was obtained every 32 msec and aligned with brachial artery pressures extrapolated from the carotid pulse tracing, allowing construction of the ascending thoracic aorta cross-sectional area/aortic pressure relationships. Aortic cross-sectional area was normalized to body surface area, and the shifts in the position for the ascending thoracic aorta cross-sectional area/aortic pressure relationship were determined with use of analysis of covariance. RESULTS: Heart rate and aortic pressure were unchanged before and after menotropin treatment. Initial estradiol levels were 2/m2 before and 403 ± 7 mm2/m2 after menotropin treatment (p <0.24). The slope of the ascending aorta cross-sectional area/aortic pressure relationship, an index of aortic compliance, increased from 1.4 ± 0.6 mm2/m2/mm Hg before to 1.7 ± 0.6 mm2/m2/mm Hg after menotropin treatment (p <0.001). CONCLUSION: In premenopausal women a short- term rise in estrogen induced by menotropin treatment is associated with an increase in aortic compliance. Aorta size is not significantly increased within this time frame.",
keywords = "Aorta, Aortic compliance, Estrogen, Menotropins",
author = "R. Chelsky and Wilson, {R. A.} and Morton, {M. J.} and Burry, {K. A.} and Phillip Patton and J. Szumowski and George Giraud and Quigley, {M. E T} and Henderson, {S. R.} and Parer, {J. T.}",
year = "1997",
doi = "10.1016/S0002-9378(97)70343-0",
language = "English (US)",
volume = "176",
pages = "1255--1261",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Alteration of ascending thoracic aorta compliance after treatment with menotropin

AU - Chelsky, R.

AU - Wilson, R. A.

AU - Morton, M. J.

AU - Burry, K. A.

AU - Patton, Phillip

AU - Szumowski, J.

AU - Giraud, George

AU - Quigley, M. E T

AU - Henderson, S. R.

AU - Parer, J. T.

PY - 1997

Y1 - 1997

N2 - OBJECTIVE: Our purpose was to determine whether aortic size and compliance are altered by an exogenously induced rise in estrogen. STUDY DESIGN: Magnetic resonance imaging was used to determine the aortic cross- sectional area/aortic pressure relationship in nine premenopausal women before and after menotropin therapy. Simultaneous electrocardiograms, carotid pulse tracings, phonocardiograms, and brachial artery pressures were obtained before each magnetic resonance imaging acquisition. Ascending thoracic aorta cross-sectional area was obtained every 32 msec and aligned with brachial artery pressures extrapolated from the carotid pulse tracing, allowing construction of the ascending thoracic aorta cross-sectional area/aortic pressure relationships. Aortic cross-sectional area was normalized to body surface area, and the shifts in the position for the ascending thoracic aorta cross-sectional area/aortic pressure relationship were determined with use of analysis of covariance. RESULTS: Heart rate and aortic pressure were unchanged before and after menotropin treatment. Initial estradiol levels were 2/m2 before and 403 ± 7 mm2/m2 after menotropin treatment (p <0.24). The slope of the ascending aorta cross-sectional area/aortic pressure relationship, an index of aortic compliance, increased from 1.4 ± 0.6 mm2/m2/mm Hg before to 1.7 ± 0.6 mm2/m2/mm Hg after menotropin treatment (p <0.001). CONCLUSION: In premenopausal women a short- term rise in estrogen induced by menotropin treatment is associated with an increase in aortic compliance. Aorta size is not significantly increased within this time frame.

AB - OBJECTIVE: Our purpose was to determine whether aortic size and compliance are altered by an exogenously induced rise in estrogen. STUDY DESIGN: Magnetic resonance imaging was used to determine the aortic cross- sectional area/aortic pressure relationship in nine premenopausal women before and after menotropin therapy. Simultaneous electrocardiograms, carotid pulse tracings, phonocardiograms, and brachial artery pressures were obtained before each magnetic resonance imaging acquisition. Ascending thoracic aorta cross-sectional area was obtained every 32 msec and aligned with brachial artery pressures extrapolated from the carotid pulse tracing, allowing construction of the ascending thoracic aorta cross-sectional area/aortic pressure relationships. Aortic cross-sectional area was normalized to body surface area, and the shifts in the position for the ascending thoracic aorta cross-sectional area/aortic pressure relationship were determined with use of analysis of covariance. RESULTS: Heart rate and aortic pressure were unchanged before and after menotropin treatment. Initial estradiol levels were 2/m2 before and 403 ± 7 mm2/m2 after menotropin treatment (p <0.24). The slope of the ascending aorta cross-sectional area/aortic pressure relationship, an index of aortic compliance, increased from 1.4 ± 0.6 mm2/m2/mm Hg before to 1.7 ± 0.6 mm2/m2/mm Hg after menotropin treatment (p <0.001). CONCLUSION: In premenopausal women a short- term rise in estrogen induced by menotropin treatment is associated with an increase in aortic compliance. Aorta size is not significantly increased within this time frame.

KW - Aorta

KW - Aortic compliance

KW - Estrogen

KW - Menotropins

UR - http://www.scopus.com/inward/record.url?scp=0030794954&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030794954&partnerID=8YFLogxK

U2 - 10.1016/S0002-9378(97)70343-0

DO - 10.1016/S0002-9378(97)70343-0

M3 - Article

C2 - 9215182

AN - SCOPUS:0030794954

VL - 176

SP - 1255

EP - 1261

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 6

ER -