Alpha-interferon administration in cytomegalovirus retinitis

Sunwen Chou, J. S. Dylewski, M. W. Gaynon, P. R. Egbert, T. C. Merigan

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Four patients, including three with the acquired immunodeficiency syndrome (AIDS), were treated with high-dose, buffy coat-derived alpha-interferon for progressive cytomegalovirus retinitis. Two of these patients had decreased viruria during therapy and the other two had increased viruria. There was evidence of progression of disease despite therapy in all patients, although the retinitis eventually became quiescent in the patient without AIDS. The severe immunosuppression encountered in AIDS patients complicates the management of cytomegalovirus and other opportunistic infections.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume25
Issue number1
StatePublished - 1984
Externally publishedYes

Fingerprint

Cytomegalovirus Retinitis
Interferon-alpha
Acquired Immunodeficiency Syndrome
Retinitis
Opportunistic Infections
Cytomegalovirus
Immunosuppression
Disease Progression
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Chou, S., Dylewski, J. S., Gaynon, M. W., Egbert, P. R., & Merigan, T. C. (1984). Alpha-interferon administration in cytomegalovirus retinitis. Antimicrobial Agents and Chemotherapy, 25(1), 25-28.

Alpha-interferon administration in cytomegalovirus retinitis. / Chou, Sunwen; Dylewski, J. S.; Gaynon, M. W.; Egbert, P. R.; Merigan, T. C.

In: Antimicrobial Agents and Chemotherapy, Vol. 25, No. 1, 1984, p. 25-28.

Research output: Contribution to journalArticle

Chou, S, Dylewski, JS, Gaynon, MW, Egbert, PR & Merigan, TC 1984, 'Alpha-interferon administration in cytomegalovirus retinitis', Antimicrobial Agents and Chemotherapy, vol. 25, no. 1, pp. 25-28.
Chou S, Dylewski JS, Gaynon MW, Egbert PR, Merigan TC. Alpha-interferon administration in cytomegalovirus retinitis. Antimicrobial Agents and Chemotherapy. 1984;25(1):25-28.
Chou, Sunwen ; Dylewski, J. S. ; Gaynon, M. W. ; Egbert, P. R. ; Merigan, T. C. / Alpha-interferon administration in cytomegalovirus retinitis. In: Antimicrobial Agents and Chemotherapy. 1984 ; Vol. 25, No. 1. pp. 25-28.
@article{076f396e92924719b0968911732b298d,
title = "Alpha-interferon administration in cytomegalovirus retinitis",
abstract = "Four patients, including three with the acquired immunodeficiency syndrome (AIDS), were treated with high-dose, buffy coat-derived alpha-interferon for progressive cytomegalovirus retinitis. Two of these patients had decreased viruria during therapy and the other two had increased viruria. There was evidence of progression of disease despite therapy in all patients, although the retinitis eventually became quiescent in the patient without AIDS. The severe immunosuppression encountered in AIDS patients complicates the management of cytomegalovirus and other opportunistic infections.",
author = "Sunwen Chou and Dylewski, {J. S.} and Gaynon, {M. W.} and Egbert, {P. R.} and Merigan, {T. C.}",
year = "1984",
language = "English (US)",
volume = "25",
pages = "25--28",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "1",

}

TY - JOUR

T1 - Alpha-interferon administration in cytomegalovirus retinitis

AU - Chou, Sunwen

AU - Dylewski, J. S.

AU - Gaynon, M. W.

AU - Egbert, P. R.

AU - Merigan, T. C.

PY - 1984

Y1 - 1984

N2 - Four patients, including three with the acquired immunodeficiency syndrome (AIDS), were treated with high-dose, buffy coat-derived alpha-interferon for progressive cytomegalovirus retinitis. Two of these patients had decreased viruria during therapy and the other two had increased viruria. There was evidence of progression of disease despite therapy in all patients, although the retinitis eventually became quiescent in the patient without AIDS. The severe immunosuppression encountered in AIDS patients complicates the management of cytomegalovirus and other opportunistic infections.

AB - Four patients, including three with the acquired immunodeficiency syndrome (AIDS), were treated with high-dose, buffy coat-derived alpha-interferon for progressive cytomegalovirus retinitis. Two of these patients had decreased viruria during therapy and the other two had increased viruria. There was evidence of progression of disease despite therapy in all patients, although the retinitis eventually became quiescent in the patient without AIDS. The severe immunosuppression encountered in AIDS patients complicates the management of cytomegalovirus and other opportunistic infections.

UR - http://www.scopus.com/inward/record.url?scp=0021353911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021353911&partnerID=8YFLogxK

M3 - Article

VL - 25

SP - 25

EP - 28

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 1

ER -