Allotransplantation of cryopreserved parathyroid tissue for severe hypocalcemia in a renal transplant recipient

S. M. Flechner, E. Berber, M. Askar, B. Stephany, A. Agarwal, Kresimira Milas

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We report the successful allotransplantation of cryopreserved parathyroid tissue to reverse hypocalcemia in a kidney transplant recipient. A 36-year-old male received a second deceased donor kidney transplant, and 6 weeks later developed severe bilateral leg numbness and weakness, inability to walk, acute pain in the left knee and wrist tetany. His total calcium was 2.6 mg/dL and parathormone level 5 pg/mL (normal 10-60 pg/mL). He underwent allotransplantation of parathyroid tissue cryopreserved for 8 months into his left brachioradialis muscle. Immunosuppression included tacrolimus (target C0 10-12 ng/mL), mycophenolate mofetil and steroids. Within 2 weeks, the left knee pain, leg weakness and numbness resolved, and by 1 month he could walk normally. After a peak at month 2, his parathyroid hormone (PTH) level fell to

Original languageEnglish (US)
Pages (from-to)2061-2065
Number of pages5
JournalAmerican Journal of Transplantation
Volume10
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

Fingerprint

Hypesthesia
Hypocalcemia
Parathyroid Hormone
Leg
Knee
Tetany
Mycophenolic Acid
Kidney
Acute Pain
Tacrolimus
Wrist
Immunosuppression
Steroids
Tissue Donors
Calcium
Transplants
Pain
Muscles
Transplant Recipients

Keywords

  • Cryopreservation
  • hypocalcemia
  • parathyroid allotransplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

Cite this

Allotransplantation of cryopreserved parathyroid tissue for severe hypocalcemia in a renal transplant recipient. / Flechner, S. M.; Berber, E.; Askar, M.; Stephany, B.; Agarwal, A.; Milas, Kresimira.

In: American Journal of Transplantation, Vol. 10, No. 9, 09.2010, p. 2061-2065.

Research output: Contribution to journalArticle

Flechner, S. M. ; Berber, E. ; Askar, M. ; Stephany, B. ; Agarwal, A. ; Milas, Kresimira. / Allotransplantation of cryopreserved parathyroid tissue for severe hypocalcemia in a renal transplant recipient. In: American Journal of Transplantation. 2010 ; Vol. 10, No. 9. pp. 2061-2065.
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