Allograft pancreas: Pale acinar nodules

Megan Troxell, Cinthia Drachenberg

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Abstract

Microscopic pale-staining acinar nodules were characterized in native pancreas in the 1980s under a variety of names but have been infrequently reported since. We retrospectively studied the frequency and characteristics of pale acinar nodules in allograft pancreas biopsies, as compared to a sampling of native pancreas specimens at our center. Pale acinar nodules were present in 13% (9/69) of allograft biopsies from 22% (7/32) of transplant patients, and 23% (5/22) of native pancreas surgical specimens, although more nodules per pancreas area were present in allograft needle biopsies. Acinar nodules had size of 100 to 700 μm, were periodic acid-Schiff pale, were synaptophysin negative, stained more weakly with keratin CAM 5.2 compared to surrounding parenchyma, and had a low proliferative rate. Ultrastructural evaluation revealed paucity of zymogen granules with dilated cistern-like structures. In our experience, pale acinar nodules have similar features in allograft and native pancreas specimens, yet remain of uncertain etiology and significance.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalHuman Pathology
Volume54
DOIs
Publication statusPublished - Aug 1 2016

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Keywords

  • Acinar nodule
  • Allograft
  • CAM52
  • Micronodule
  • Pancreas
  • PASd

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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