Allogeneic stem-cell transplantation in renal-cell carcinoma.

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Metastatic renal-cell carcinoma (RCC) remains resistant to nearly all standard cytotoxic therapies, but immune-based cytokine therapies benefit a small minority of patients with advanced RCC. Nonmyeloablative allogeneic stem-cell transplantation is a novel approach to harnessing the immune system to combat this cancer. The strategy relies on a T-cell graft-versus-malignancy effect mediated by donor T cells. Preliminary work in using nonmyeloablative allogeneic stem-cell transplant in RCC has identified a graft-versus-RCC effect and yielded encouraging clinical responses.

Original languageEnglish (US)
Pages (from-to)433-437
Number of pages5
JournalCurrent oncology reports
Issue number5
StatePublished - Sep 2001

ASJC Scopus subject areas

  • Oncology


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