Allogeneic stem-cell transplantation in renal-cell carcinoma.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Metastatic renal-cell carcinoma (RCC) remains resistant to nearly all standard cytotoxic therapies, but immune-based cytokine therapies benefit a small minority of patients with advanced RCC. Nonmyeloablative allogeneic stem-cell transplantation is a novel approach to harnessing the immune system to combat this cancer. The strategy relies on a T-cell graft-versus-malignancy effect mediated by donor T cells. Preliminary work in using nonmyeloablative allogeneic stem-cell transplant in RCC has identified a graft-versus-RCC effect and yielded encouraging clinical responses.

Original languageEnglish (US)
Pages (from-to)433-437
Number of pages5
JournalCurrent Oncology Reports
Volume3
Issue number5
StatePublished - Sep 2001

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Stem Cell Transplantation
Renal Cell Carcinoma
Transplants
T-Lymphocytes
Immune System
Neoplasms
Stem Cells
Tissue Donors
Cytokines
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Allogeneic stem-cell transplantation in renal-cell carcinoma. / Hayes-Lattin, Brandon; Maziarz, Richard; Beer, Tomasz (Tom).

In: Current Oncology Reports, Vol. 3, No. 5, 09.2001, p. 433-437.

Research output: Contribution to journalArticle

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