Allogeneic stem-cell transplantation in renal-cell carcinoma.

B. M. Hayes-Lattin; R. T. Maziarz; T. M. Beer

doi:10.1007/s11912-001-0030-7

Allogeneic stem-cell transplantation in renal-cell carcinoma.

B. M. Hayes-Lattin, R. T. Maziarz, T. M. Beer

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Metastatic renal-cell carcinoma (RCC) remains resistant to nearly all standard cytotoxic therapies, but immune-based cytokine therapies benefit a small minority of patients with advanced RCC. Nonmyeloablative allogeneic stem-cell transplantation is a novel approach to harnessing the immune system to combat this cancer. The strategy relies on a T-cell graft-versus-malignancy effect mediated by donor T cells. Preliminary work in using nonmyeloablative allogeneic stem-cell transplant in RCC has identified a graft-versus-RCC effect and yielded encouraging clinical responses.

Original language	English (US)
Pages (from-to)	433-437
Number of pages	5
Journal	Current oncology reports
Volume	3
Issue number	5
DOIs	https://doi.org/10.1007/s11912-001-0030-7
State	Published - Sep 2001

ASJC Scopus subject areas

Oncology

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title = "Allogeneic stem-cell transplantation in renal-cell carcinoma.",

abstract = "Metastatic renal-cell carcinoma (RCC) remains resistant to nearly all standard cytotoxic therapies, but immune-based cytokine therapies benefit a small minority of patients with advanced RCC. Nonmyeloablative allogeneic stem-cell transplantation is a novel approach to harnessing the immune system to combat this cancer. The strategy relies on a T-cell graft-versus-malignancy effect mediated by donor T cells. Preliminary work in using nonmyeloablative allogeneic stem-cell transplant in RCC has identified a graft-versus-RCC effect and yielded encouraging clinical responses.",

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AU - Beer, T. M.

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N2 - Metastatic renal-cell carcinoma (RCC) remains resistant to nearly all standard cytotoxic therapies, but immune-based cytokine therapies benefit a small minority of patients with advanced RCC. Nonmyeloablative allogeneic stem-cell transplantation is a novel approach to harnessing the immune system to combat this cancer. The strategy relies on a T-cell graft-versus-malignancy effect mediated by donor T cells. Preliminary work in using nonmyeloablative allogeneic stem-cell transplant in RCC has identified a graft-versus-RCC effect and yielded encouraging clinical responses.

AB - Metastatic renal-cell carcinoma (RCC) remains resistant to nearly all standard cytotoxic therapies, but immune-based cytokine therapies benefit a small minority of patients with advanced RCC. Nonmyeloablative allogeneic stem-cell transplantation is a novel approach to harnessing the immune system to combat this cancer. The strategy relies on a T-cell graft-versus-malignancy effect mediated by donor T cells. Preliminary work in using nonmyeloablative allogeneic stem-cell transplant in RCC has identified a graft-versus-RCC effect and yielded encouraging clinical responses.

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Allogeneic stem-cell transplantation in renal-cell carcinoma.

Abstract

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