Allogeneic bone marrow transplantation for refractory and recurrent low-grade lymphoma: The case for aggressive management

Koen W. Van Besien, Issa F. Khouri, Sergio A. Giralt, Philip McCarthy, Rakesh Mehra, Borje S. Andersson, Donna Przepiorka, James L. Gajewski, Nagendranath Bellare, Rajneesh Nath, Jorge E. Romaguera, Peter McLaughlin, Martin Korbling, Albert B. Deisseroth, Fernando F. Cabanillas, Richard E. Champlin

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    106 Scopus citations

    Abstract

    Purpose: To evaluate the role of allogeneic bone marrow transplantation (BMT) in recurrent low-grade lymphoma. Patients and Methods: Between 1989 and 1994, 10 patients with chemotherapy-refractory and recurrent low-grade lymphoma were treated with myeloablative therapy and allogeneic BMT. All patients had poor prognostic features and had been extensively pretreated. Results: Eight patients achieved a complete remission and none have relapsed at a median follow-up time of 816 days (range, 346 to 1,865). Two patients died of early complications. The actuarial survival and failure-free survival rates are both 80% ± 12.6%. For surviving patients, the duration of the current remission exceeds that of any previous remission achieved. Conclusion: These results compare favorably with those for autologous BMT, Allogeneic BMT offers considerable promise for the treatment of patients with poorprognosis low-grade lymphoma. Its role should be further defined in prospective studies.

    Original languageEnglish (US)
    Pages (from-to)1096-1102
    Number of pages7
    JournalJournal of Clinical Oncology
    Volume13
    Issue number5
    DOIs
    StatePublished - May 1995

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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    Van Besien, K. W., Khouri, I. F., Giralt, S. A., McCarthy, P., Mehra, R., Andersson, B. S., Przepiorka, D., Gajewski, J. L., Bellare, N., Nath, R., Romaguera, J. E., McLaughlin, P., Korbling, M., Deisseroth, A. B., Cabanillas, F. F., & Champlin, R. E. (1995). Allogeneic bone marrow transplantation for refractory and recurrent low-grade lymphoma: The case for aggressive management. Journal of Clinical Oncology, 13(5), 1096-1102. https://doi.org/10.1200/JCO.1995.13.5.1096