TY - JOUR
T1 - Allergic Contact Dermatitis Caused by Idoxuridine
T2 - Patterns of Cross Reactivity With Other Pyrimidine Analogues
AU - Amon, Robert B.
AU - Lis, Adam W.
AU - Hanifin, Jon M.
PY - 1975/12
Y1 - 1975/12
N2 - Idoxuridine has been used for many years in the treatment of herpex simplex infections of the eye. Use of the drug for herpes simplex infection of the skin is increasing. Ophthalmologists have noted occasional conjunctival and corneal irritant reactions, but no true delayed cutaneous hypersensitivity has been verified. We report four cases of allergic contact dermatitis from idoxuridine, sensitized by both eye and skin applications. Cross reactivity to brominated and chlorinated, but not fluorinated, pyrimidine analogues is noted. Extensive patch testing indicates the general relationship between the structure of pyrimidine compounds and their antigenic cross reactivity.
AB - Idoxuridine has been used for many years in the treatment of herpex simplex infections of the eye. Use of the drug for herpes simplex infection of the skin is increasing. Ophthalmologists have noted occasional conjunctival and corneal irritant reactions, but no true delayed cutaneous hypersensitivity has been verified. We report four cases of allergic contact dermatitis from idoxuridine, sensitized by both eye and skin applications. Cross reactivity to brominated and chlorinated, but not fluorinated, pyrimidine analogues is noted. Extensive patch testing indicates the general relationship between the structure of pyrimidine compounds and their antigenic cross reactivity.
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U2 - 10.1001/archderm.1975.01630240037006
DO - 10.1001/archderm.1975.01630240037006
M3 - Article
C2 - 128325
AN - SCOPUS:0016724499
SN - 0003-987X
VL - 111
SP - 1581
EP - 1584
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 12
ER -