ALK rearrangements in infantile fibrosarcoma-like spindle cell tumours of soft tissue and kidney

Serena Y. Tan, Alyaa Al-Ibraheemi, William A. Ahrens, Javier E. Oesterheld, Julie C. Fanburg-Smith, Yajuan J. Liu, Sheri L. Spunt, Erin R. Rudzinski, Cheryl Coffin, Jessica L. Davis

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Aims: Recurrent alterations in receptor tyrosine kinase (RTK) and downstream effectors are described in infantile fibrosarcoma (IFS)/cellular congenital mesoblastic nephroma (cCMN) and a subset of spindle cell sarcomas, provisionally designated ‘NTRK-rearranged’ spindle cell neoplasms. These two groups of tumours demonstrate overlapping morphologies and harbour alterations in NTRK1/2/3, RET, MET, ABL1, ROS1, RAF1 and BRAF, although their relationship is not fully elucidated. We describe herein a cohort of paediatric tumours with clinicopathological features not typical for inflammatory myofibroblastic tumour, but rather with similarities to cCMN/IFS harbouring ALK fusions. Methods and results: Clinicopathological features were assessed and partner agnostic targeted RNA sequencing on clinically validated platforms were performed. Tumours occurred in patients aged from 2 to 10 years (median age 2 years) with a 2:2 male to female ratio and an average size of 8.4 cm. Two tumours arose in soft tissues and two in the kidney. Morphological features included spindle to ovoid cells arranged in long fascicles or haphazardly within a myxoid to collagenised stroma; a subset of cases had either dilated, ectatic vessels or focal perivascular hyalinosis. By immunohistochemistry, all cases tested showed cytoplasmic expression of anaplastic lymphoma kinase (ALK) and one case demonstrated co-expression of CD34 and S100. Conclusions: This series of ALK-rearranged IFS-like tumours expands the spectrum of targetable kinases altered in these tumours and reinforces the potential overlap between IFS/cCMN-like tumours and the provisional entity of ‘NTRK-rearranged’ spindle cell neoplasms.

Original languageEnglish (US)
Pages (from-to)698-707
Number of pages10
JournalHistopathology
Volume80
Issue number4
DOIs
StatePublished - Mar 2022
Externally publishedYes

Keywords

  • ALK
  • CD34
  • crizotinib
  • fibrosarcoma
  • infantile fibrosarcoma
  • inflammatory myofibroblastic tumour
  • NTRK-rearranged spindle cell neoplasm
  • S100

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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