Alcoholism

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Alcohol-use disorders develop over a protracted course, beginning with social experimentation, to repeated binge-like indulgence, to use despite personal, social, and/or legal consequences, and ultimately to dependence. A growing body of evidence indicates that developmental factors have an impact on risk for the development of alcoholism, such that use of alcohol during or before adolescence increases the probability of an alcohol abuse or dependence diagnosis later in life. In addition, genetic differences among individuals have an influence on risk. A formidable task has been identifying the influential genes, their connections within biochemical pathways, and their interactions with environmental factors that may alter the path of disease development. Though this task is not complete, newer technologies have allowed for the large-scale human and animal model studies that will be required to determine whether biological markers for risk for alcohol disorders can be found and can be used to develop better therapies.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages62-64
Number of pages3
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
StatePublished - Feb 27 2013

Fingerprint

alcohol abuse
Alcoholism
alcohols
Alcohols
adolescence
Delayed Diagnosis
Individuality
biochemical pathways
biomarkers
Animal Models
Biomarkers
animal models
Technology
therapeutics
Animals
environmental factors
Genes
genes
Therapeutics

Keywords

  • Alcohol metabolism
  • Case-control
  • Dopamine
  • GABA
  • Gene expression
  • GWAS
  • Knockout
  • Microarray
  • Mpdz
  • Neuropeptide Y
  • Opioid
  • QTL
  • Selected lines

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Phillips, T. (2013). Alcoholism. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 62-64). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.00028-0

Alcoholism. / Phillips, Tamara.

Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., 2013. p. 62-64.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phillips, T 2013, Alcoholism. in Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., pp. 62-64. https://doi.org/10.1016/B978-0-12-374984-0.00028-0
Phillips T. Alcoholism. In Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc. 2013. p. 62-64 https://doi.org/10.1016/B978-0-12-374984-0.00028-0
Phillips, Tamara. / Alcoholism. Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., 2013. pp. 62-64
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