Alcohol withdrawal severity in inbred mouse (Mus musculus) strains

Pamela Metten, John Jr Crabbe

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Male mice (Mus musculus) from 15 standard inbred strains were exposed to a nearly constant concentration of ethanol (EtOH) vapor for 72 hr, averaging 1.59 ± 0.03 mg EtOH/mL blood at withdrawal. EtOH- and air-exposed groups were tested hourly for handling-induced convulsions for 10 hr and at Hours 24 and 25. Strains differed markedly in the severity of withdrawal (after subtraction of control values), and by design these differences were independent of strain differences in EtOH metabolism. Correlation of strain mean withdrawal severity with other responses to EtOH supported previously reported genetic relationships of high EtOH withdrawal with low drinking, high conditioned taste aversion, low tolerance to EtOH-induced hypothermia, and high stimulated activity after low-dose EtOH. Also supported were the positive genetic correlations among EtOH, barbiturate, and benzodiazepine withdrawal. Sensitivity of naive mice to several chemical convulsant-induced seizures was also correlated with EtOH withdrawal.

Original languageEnglish (US)
Pages (from-to)911-925
Number of pages15
JournalBehavioral Neuroscience
Volume119
Issue number4
DOIs
StatePublished - Aug 2005
Externally publishedYes

Fingerprint

Alcohols
Seizures
Induced Hypothermia
Convulsants
Benzodiazepines
Drinking
Ethanol
Air
barbituric acid
Handling (Psychology)

Keywords

  • Dependence
  • Ethanol
  • Handling-induced convulsions
  • Inbred mouse strains
  • Pharmacogenetics

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. / Metten, Pamela; Crabbe, John Jr.

In: Behavioral Neuroscience, Vol. 119, No. 4, 08.2005, p. 911-925.

Research output: Contribution to journalArticle

@article{3a39fc61198e4a6ba75c958fad5ad91d,
title = "Alcohol withdrawal severity in inbred mouse (Mus musculus) strains",
abstract = "Male mice (Mus musculus) from 15 standard inbred strains were exposed to a nearly constant concentration of ethanol (EtOH) vapor for 72 hr, averaging 1.59 ± 0.03 mg EtOH/mL blood at withdrawal. EtOH- and air-exposed groups were tested hourly for handling-induced convulsions for 10 hr and at Hours 24 and 25. Strains differed markedly in the severity of withdrawal (after subtraction of control values), and by design these differences were independent of strain differences in EtOH metabolism. Correlation of strain mean withdrawal severity with other responses to EtOH supported previously reported genetic relationships of high EtOH withdrawal with low drinking, high conditioned taste aversion, low tolerance to EtOH-induced hypothermia, and high stimulated activity after low-dose EtOH. Also supported were the positive genetic correlations among EtOH, barbiturate, and benzodiazepine withdrawal. Sensitivity of naive mice to several chemical convulsant-induced seizures was also correlated with EtOH withdrawal.",
keywords = "Dependence, Ethanol, Handling-induced convulsions, Inbred mouse strains, Pharmacogenetics",
author = "Pamela Metten and Crabbe, {John Jr}",
year = "2005",
month = "8",
doi = "10.1037/0735-7044.119.4.911",
language = "English (US)",
volume = "119",
pages = "911--925",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "4",

}

TY - JOUR

T1 - Alcohol withdrawal severity in inbred mouse (Mus musculus) strains

AU - Metten, Pamela

AU - Crabbe, John Jr

PY - 2005/8

Y1 - 2005/8

N2 - Male mice (Mus musculus) from 15 standard inbred strains were exposed to a nearly constant concentration of ethanol (EtOH) vapor for 72 hr, averaging 1.59 ± 0.03 mg EtOH/mL blood at withdrawal. EtOH- and air-exposed groups were tested hourly for handling-induced convulsions for 10 hr and at Hours 24 and 25. Strains differed markedly in the severity of withdrawal (after subtraction of control values), and by design these differences were independent of strain differences in EtOH metabolism. Correlation of strain mean withdrawal severity with other responses to EtOH supported previously reported genetic relationships of high EtOH withdrawal with low drinking, high conditioned taste aversion, low tolerance to EtOH-induced hypothermia, and high stimulated activity after low-dose EtOH. Also supported were the positive genetic correlations among EtOH, barbiturate, and benzodiazepine withdrawal. Sensitivity of naive mice to several chemical convulsant-induced seizures was also correlated with EtOH withdrawal.

AB - Male mice (Mus musculus) from 15 standard inbred strains were exposed to a nearly constant concentration of ethanol (EtOH) vapor for 72 hr, averaging 1.59 ± 0.03 mg EtOH/mL blood at withdrawal. EtOH- and air-exposed groups were tested hourly for handling-induced convulsions for 10 hr and at Hours 24 and 25. Strains differed markedly in the severity of withdrawal (after subtraction of control values), and by design these differences were independent of strain differences in EtOH metabolism. Correlation of strain mean withdrawal severity with other responses to EtOH supported previously reported genetic relationships of high EtOH withdrawal with low drinking, high conditioned taste aversion, low tolerance to EtOH-induced hypothermia, and high stimulated activity after low-dose EtOH. Also supported were the positive genetic correlations among EtOH, barbiturate, and benzodiazepine withdrawal. Sensitivity of naive mice to several chemical convulsant-induced seizures was also correlated with EtOH withdrawal.

KW - Dependence

KW - Ethanol

KW - Handling-induced convulsions

KW - Inbred mouse strains

KW - Pharmacogenetics

UR - http://www.scopus.com/inward/record.url?scp=25444449001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25444449001&partnerID=8YFLogxK

U2 - 10.1037/0735-7044.119.4.911

DO - 10.1037/0735-7044.119.4.911

M3 - Article

C2 - 16187819

AN - SCOPUS:25444449001

VL - 119

SP - 911

EP - 925

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 4

ER -