Alcohol withdrawal and magnesium deficiency in mice

J. K. Belknap, J. H. Berg, R. R. Coleman

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

DBA/2J mice exposed to chronic alcohol (ethanol) intoxication were found to have lower whole brain magnesium (Mg) concentrations than control animals. The symptoms of alcohol withdrawal were found to be strikingly similar to those seen in Mg deficient mice exposed to a low Mg diet without alcohol exposure. These findings suggest that CNS Mg deficits produced by alcohol exposure could contribute to the observed alcohol withdrawal syndrome. Serum Mg concentrations were also determined, and low correlations (≤0.3) were found with brain Mg concentrations.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume9
Issue number1
DOIs
StatePublished - Jul 1978

    Fingerprint

Keywords

  • Alcohol withdrawal
  • DBA/2J mice
  • Magnesium deficiency

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this