Alcohol psychopharmacogenetics

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Of all drugs of abuse studied to determine genetic contributions to susceptibility to their effects, alcohol has been by far the most frequent focus. Both animal model and human genetic studies will be mentioned here. A historically rich literature with genetic animal models has explored the general contribution of genetics to alcohol responsiveness, and has been helpful in elucidating the drug’s mechanism of action on the nervous system. Some studies using genetic animal models have attempted to identify specific genes that increase or decrease responsiveness for a number of alcohol’s effects. Most human studies have been of alcoholics and their relatives, and have compared relative risks for alcohol dependence disorders in twins, adoptees, or other relatives. More recently, human studies have also addressed the goal of identifying individual genes that might contribute to alcoholism risk, or to individual differences in endophenotypes, which also are associated with alcoholism risk.

Original languageEnglish (US)
Title of host publicationNeurobehavioral Genetics
Subtitle of host publicationMethods and Applications, Second Edition
PublisherCRC Press
Pages457-468
Number of pages12
ISBN (Electronic)9781420003567
ISBN (Print)084931903X, 9780849319037
StatePublished - Jan 1 2006

Fingerprint

Alcoholism
Animal Models
Genetic Models
Alcohols
Animals
Endophenotypes
Genes
Medical Genetics
Street Drugs
Alcoholics
Individuality
Nervous System
Neurology
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Crabbe, J. J. (2006). Alcohol psychopharmacogenetics. In Neurobehavioral Genetics: Methods and Applications, Second Edition (pp. 457-468). CRC Press.

Alcohol psychopharmacogenetics. / Crabbe, John Jr.

Neurobehavioral Genetics: Methods and Applications, Second Edition. CRC Press, 2006. p. 457-468.

Research output: Chapter in Book/Report/Conference proceedingChapter

Crabbe, JJ 2006, Alcohol psychopharmacogenetics. in Neurobehavioral Genetics: Methods and Applications, Second Edition. CRC Press, pp. 457-468.
Crabbe JJ. Alcohol psychopharmacogenetics. In Neurobehavioral Genetics: Methods and Applications, Second Edition. CRC Press. 2006. p. 457-468
Crabbe, John Jr. / Alcohol psychopharmacogenetics. Neurobehavioral Genetics: Methods and Applications, Second Edition. CRC Press, 2006. pp. 457-468
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