Abstract
Of all drugs of abuse studied to determine genetic contributions to susceptibility to their effects, alcohol has been by far the most frequent focus. Both animal model and human genetic studies will be mentioned here. A historically rich literature with genetic animal models has explored the general contribution of genetics to alcohol responsiveness, and has been helpful in elucidating the drug’s mechanism of action on the nervous system. Some studies using genetic animal models have attempted to identify specific genes that increase or decrease responsiveness for a number of alcohol’s effects. Most human studies have been of alcoholics and their relatives, and have compared relative risks for alcohol dependence disorders in twins, adoptees, or other relatives. More recently, human studies have also addressed the goal of identifying individual genes that might contribute to alcoholism risk, or to individual differences in endophenotypes, which also are associated with alcoholism risk.
| Original language | English (US) |
|---|---|
| Title of host publication | Neurobehavioral Genetics |
| Subtitle of host publication | Methods and Applications, Second Edition |
| Publisher | CRC Press |
| Pages | 457-468 |
| Number of pages | 12 |
| ISBN (Electronic) | 9781420003567 |
| ISBN (Print) | 084931903X, 9780849319037 |
| State | Published - Jan 1 2006 |
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ASJC Scopus subject areas
- Neuroscience(all)
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Alcohol psychopharmacogenetics. / Crabbe, John Jr.
Neurobehavioral Genetics: Methods and Applications, Second Edition. CRC Press, 2006. p. 457-468.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Alcohol psychopharmacogenetics
AU - Crabbe, John Jr
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Of all drugs of abuse studied to determine genetic contributions to susceptibility to their effects, alcohol has been by far the most frequent focus. Both animal model and human genetic studies will be mentioned here. A historically rich literature with genetic animal models has explored the general contribution of genetics to alcohol responsiveness, and has been helpful in elucidating the drug’s mechanism of action on the nervous system. Some studies using genetic animal models have attempted to identify specific genes that increase or decrease responsiveness for a number of alcohol’s effects. Most human studies have been of alcoholics and their relatives, and have compared relative risks for alcohol dependence disorders in twins, adoptees, or other relatives. More recently, human studies have also addressed the goal of identifying individual genes that might contribute to alcoholism risk, or to individual differences in endophenotypes, which also are associated with alcoholism risk.
AB - Of all drugs of abuse studied to determine genetic contributions to susceptibility to their effects, alcohol has been by far the most frequent focus. Both animal model and human genetic studies will be mentioned here. A historically rich literature with genetic animal models has explored the general contribution of genetics to alcohol responsiveness, and has been helpful in elucidating the drug’s mechanism of action on the nervous system. Some studies using genetic animal models have attempted to identify specific genes that increase or decrease responsiveness for a number of alcohol’s effects. Most human studies have been of alcoholics and their relatives, and have compared relative risks for alcohol dependence disorders in twins, adoptees, or other relatives. More recently, human studies have also addressed the goal of identifying individual genes that might contribute to alcoholism risk, or to individual differences in endophenotypes, which also are associated with alcoholism risk.
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M3 - Chapter
SN - 084931903X
SN - 9780849319037
SP - 457
EP - 468
BT - Neurobehavioral Genetics
PB - CRC Press
ER -