Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors

Tamara Phillips, Kelly J. Brown, Sue Burkhart-Kasch, Charlotte D. Wenger, Michele A. Kelly, Marcelo Rubinstein, David Grandy, Malcolm J. Low

Research output: Contribution to journalArticle

Abstract

Although dopaminergic transmission has been strongly implicated in alcohol self-administration, the involvement of specific dopamine receptor subtypes has not been well established. We studied the ethanol preference and sensitivity of D2-receptor-deficient mice to directly evaluate whether dopamine D2 receptors contribute to alcohol (ethanol) consumption. We report a marked aversion to ethanol in these mice, relative to the high preference and consumption exhibited by wild-type littermates. Sensitivity to ethanol-induced locomotor impairment was also reduced in these mutant mice, although they showed a normal locomotor depressant response to the dopamine D1 antagonist SCH-23390. These data demonstrate that dopamine signaling via D2 receptors is an essential component of the molecular pathway determining ethanol self-administration and sensitivity.

Original languageEnglish (US)
Pages (from-to)610-615
Number of pages6
JournalMolecular Cell
Volume1
Issue number7
StatePublished - 1998

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Ethanol
Alcohols
Self Administration
Dopamine Antagonists
Dopamine D2 Receptors
Dopamine Receptors
Alcohol Drinking
Dopamine
mouse DRD2 protein

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Phillips, T., Brown, K. J., Burkhart-Kasch, S., Wenger, C. D., Kelly, M. A., Rubinstein, M., ... Low, M. J. (1998). Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Molecular Cell, 1(7), 610-615.

Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. / Phillips, Tamara; Brown, Kelly J.; Burkhart-Kasch, Sue; Wenger, Charlotte D.; Kelly, Michele A.; Rubinstein, Marcelo; Grandy, David; Low, Malcolm J.

In: Molecular Cell, Vol. 1, No. 7, 1998, p. 610-615.

Research output: Contribution to journalArticle

Phillips, T, Brown, KJ, Burkhart-Kasch, S, Wenger, CD, Kelly, MA, Rubinstein, M, Grandy, D & Low, MJ 1998, 'Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors', Molecular Cell, vol. 1, no. 7, pp. 610-615.
Phillips T, Brown KJ, Burkhart-Kasch S, Wenger CD, Kelly MA, Rubinstein M et al. Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Molecular Cell. 1998;1(7):610-615.
Phillips, Tamara ; Brown, Kelly J. ; Burkhart-Kasch, Sue ; Wenger, Charlotte D. ; Kelly, Michele A. ; Rubinstein, Marcelo ; Grandy, David ; Low, Malcolm J. / Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. In: Molecular Cell. 1998 ; Vol. 1, No. 7. pp. 610-615.
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