Abstract
Alcohol metabolism's various processes create harmful compounds that contribute to cell and tissue damage. In particular, the enzyme cytochrome P450 2E1 (CYP2E1) plays a role in creating a harmful condition known as oxidative stress. This condition is related to oxygen's ability to accept electrons and the subsequent highly reactive and harmful byproducts created by these chemical reactions. CYP2E1's use of oxygen in alcohol metabolism generates reactive oxygen species, ultimately leading to oxidative stress and tissue damage.
Original language | English (US) |
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Pages (from-to) | 274-280 |
Number of pages | 7 |
Journal | Alcohol Research and Health |
Volume | 29 |
Issue number | 4 |
State | Published - 2006 |
Keywords
- Acetaldehyde
- Alcohol dehydrogenase
- Alcohol liver disorder
- Cytochrome p450 2E1 (CYP2E1)
- Ethanol metabolism
- Mitochondria
- Oxidative stress
- Reactive oxygen species (ROS)
- Superoxide
- Toxicity
ASJC Scopus subject areas
- Medicine (miscellaneous)