Alcohol metabolism's damaging effects on the cell: A focus on reactive oxygen generation by the enzyme cytochrome P450 2E1

Research output: Contribution to journalReview article

65 Scopus citations

Abstract

Alcohol metabolism's various processes create harmful compounds that contribute to cell and tissue damage. In particular, the enzyme cytochrome P450 2E1 (CYP2E1) plays a role in creating a harmful condition known as oxidative stress. This condition is related to oxygen's ability to accept electrons and the subsequent highly reactive and harmful byproducts created by these chemical reactions. CYP2E1's use of oxygen in alcohol metabolism generates reactive oxygen species, ultimately leading to oxidative stress and tissue damage.

Original languageEnglish (US)
Pages (from-to)274-280
Number of pages7
JournalAlcohol Research and Health
Volume29
Issue number4
StatePublished - Dec 1 2006

Keywords

  • Acetaldehyde
  • Alcohol dehydrogenase
  • Alcohol liver disorder
  • Cytochrome p450 2E1 (CYP2E1)
  • Ethanol metabolism
  • Mitochondria
  • Oxidative stress
  • Reactive oxygen species (ROS)
  • Superoxide
  • Toxicity

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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