Alcohol-inducible cytochrome P-450 (P-450ALC)

Minor J. Coon; Dennis R. Koop

doi:10.1007/BF00296940

Alcohol-inducible cytochrome P-450 (P-450_ALC)

Minor J. Coon, Dennis R. Koop

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

Of the family of P-450 cytochromes occurring in rabbit liver microsomes, only isozyme 3 a (P-450_ALC) is induced by alcohol administration and is effective in catalyzing the reaction: ethanol+0₂+NADPH+H⁺ → acetaldehyde +2H₂O+NADP⁺. As judged by immuno-chemical quantitation, P-450_ALC is also induced in the animals by other diverse agents, including imidazole, trichlorethylene, acetone, pyrazole, and isoniazid. Evidence has been obtained for the occurrence of a protein immuno-chemically related to P-450_ALC in human liver microsomes and of a similar alcohol-inducible protein in the rat and in the normal and alcohol dehydrogenase-deficient deer-mouse. P-450_ALC catalyzes the activation of foreign compounds such as acetaminophen, various nitrosamines, and carbon tetrachloride and is therefore believed to play an important role in the enhanced toxicity of these substances accompanying alcohol administration

Original language	English (US)
Pages (from-to)	16-21
Number of pages	6
Journal	Archives of Toxicology
Volume	60
Issue number	1-3
DOIs	https://doi.org/10.1007/BF00296940
State	Published - May 1987
Externally published	Yes

Keywords

Acetaminophen
Butanol
Carbon tetrachloride
Cocaine
Cytochrome P-450
Ethanol
Induction
Nitrosamines
Toxicity

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis

Access to Document

10.1007/BF00296940

Cite this

@article{60df58dc502846d2b55fcdb90ca16b68,

title = "Alcohol-inducible cytochrome P-450 (P-450ALC)",

abstract = "Of the family of P-450 cytochromes occurring in rabbit liver microsomes, only isozyme 3 a (P-450ALC) is induced by alcohol administration and is effective in catalyzing the reaction: ethanol+02+NADPH+H+ → acetaldehyde +2H2O+NADP+. As judged by immuno-chemical quantitation, P-450ALC is also induced in the animals by other diverse agents, including imidazole, trichlorethylene, acetone, pyrazole, and isoniazid. Evidence has been obtained for the occurrence of a protein immuno-chemically related to P-450ALC in human liver microsomes and of a similar alcohol-inducible protein in the rat and in the normal and alcohol dehydrogenase-deficient deer-mouse. P-450ALC catalyzes the activation of foreign compounds such as acetaminophen, various nitrosamines, and carbon tetrachloride and is therefore believed to play an important role in the enhanced toxicity of these substances accompanying alcohol administration",

keywords = "Acetaminophen, Butanol, Carbon tetrachloride, Cocaine, Cytochrome P-450, Ethanol, Induction, Nitrosamines, Toxicity",

author = "Coon, {Minor J.} and Koop, {Dennis R.}",

year = "1987",

month = may,

doi = "10.1007/BF00296940",

language = "English (US)",

volume = "60",

pages = "16--21",

journal = "Archives of Toxicology",

issn = "0340-5761",

publisher = "Springer Verlag",

number = "1-3",

}

TY - JOUR

T1 - Alcohol-inducible cytochrome P-450 (P-450ALC)

AU - Coon, Minor J.

AU - Koop, Dennis R.

PY - 1987/5

Y1 - 1987/5

N2 - Of the family of P-450 cytochromes occurring in rabbit liver microsomes, only isozyme 3 a (P-450ALC) is induced by alcohol administration and is effective in catalyzing the reaction: ethanol+02+NADPH+H+ → acetaldehyde +2H2O+NADP+. As judged by immuno-chemical quantitation, P-450ALC is also induced in the animals by other diverse agents, including imidazole, trichlorethylene, acetone, pyrazole, and isoniazid. Evidence has been obtained for the occurrence of a protein immuno-chemically related to P-450ALC in human liver microsomes and of a similar alcohol-inducible protein in the rat and in the normal and alcohol dehydrogenase-deficient deer-mouse. P-450ALC catalyzes the activation of foreign compounds such as acetaminophen, various nitrosamines, and carbon tetrachloride and is therefore believed to play an important role in the enhanced toxicity of these substances accompanying alcohol administration

AB - Of the family of P-450 cytochromes occurring in rabbit liver microsomes, only isozyme 3 a (P-450ALC) is induced by alcohol administration and is effective in catalyzing the reaction: ethanol+02+NADPH+H+ → acetaldehyde +2H2O+NADP+. As judged by immuno-chemical quantitation, P-450ALC is also induced in the animals by other diverse agents, including imidazole, trichlorethylene, acetone, pyrazole, and isoniazid. Evidence has been obtained for the occurrence of a protein immuno-chemically related to P-450ALC in human liver microsomes and of a similar alcohol-inducible protein in the rat and in the normal and alcohol dehydrogenase-deficient deer-mouse. P-450ALC catalyzes the activation of foreign compounds such as acetaminophen, various nitrosamines, and carbon tetrachloride and is therefore believed to play an important role in the enhanced toxicity of these substances accompanying alcohol administration

KW - Acetaminophen

KW - Butanol

KW - Carbon tetrachloride

KW - Cocaine

KW - Cytochrome P-450

KW - Ethanol

KW - Induction

KW - Nitrosamines

KW - Toxicity

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U2 - 10.1007/BF00296940

DO - 10.1007/BF00296940

M3 - Review article

C2 - 3304205

AN - SCOPUS:0023213778

SN - 0340-5761

VL - 60

SP - 16

EP - 21

JO - Archives of Toxicology

JF - Archives of Toxicology

IS - 1-3

ER -