Alcohol and other substance use after bariatric surgery: Prospective evidence from a U.S. multicenter cohort study

Wendy C. King, Jia Yuh Chen, Anita P. Courcoulas, Gregory F. Dakin, Scott G. Engel, David R. Flum, Marcelo W. Hinojosa, Melissa A. Kalarchian, Samer Mattar, James E. Mitchell, Alfons Pomp, Walter J. Pories, Kristine J. Steffen, Gretchen E. White, Bruce Wolfe, Susan Z. Yanovski

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Empirical evidence suggests Roux-en-Y gastric bypass (RYGB) increases risk of developing alcohol use disorder (AUD). However, prospective assessment of substance use disorders (SUD) after bariatric surgery is limited. Objective: To report SUD-related outcomes after RYGB and laparoscopic adjustable gastric banding (LAGB). To identify factors associated with incident SUD-related outcomes. Setting: 10 U.S. hospitals. Methods: The Longitudinal Assessment of Bariatric Surgery-2 is a prospective cohort study. Participants self-reported past-year AUD symptoms (determined by the Alcohol Use Disorders Identification Test), illicit drug use (cocaine, hallucinogens, inhalants, phencyclidine, amphetamines, or marijuana), and SUD treatment (counseling or hospitalization for alcohol or drugs) presurgery and annually postsurgery for up to 7 years through January 2015. Results: Of 2348 participants who underwent RYGB or LAGB, 2003 completed baseline and follow-up assessments (79.2% women, baseline median age: 47 years, median body mass index 45.6). The year-5 cumulative incidence of postsurgery onset AUD symptoms, illicit drug use, and SUD treatment were 20.8% (95% confidence interval (CI): 18.5-23.3), 7.5% (95% CI: 6.1-9.1), and 3.5% (95% CI: 2.6-4.8), respectively, post-RYGB, and 11.3% (95% CI: 8.5-14.9), 4.9% (95% CI: 3.1-7.6), and .9% (95% CI: .4-2.5) post-LAGB. Undergoing RYGB versus LAGB was associated with higher risk of incident AUD symptoms (adjusted hazard ratio or AHR = 2.08 [95% CI: 1.51-2.85]), illicit drug use (AHR = 1.76 [95% CI: 1.07-2.90]) and SUD treatment (AHR = 3.56 [95% CI: 1.26-10.07]). Conclusions: Undergoing RYGB versus LAGB was associated with twice the risk of incident AUD symptoms. One-fifth of participants reported incident AUD symptoms within 5 years post-RYGB. AUD education, screening, evaluation, and treatment referral should be incorporated in pre- and postoperative care.

Original languageEnglish (US)
JournalSurgery for Obesity and Related Diseases
DOIs
StateAccepted/In press - Jan 17 2017

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Bariatric Surgery
Gastric Bypass
Multicenter Studies
Cohort Studies
Alcohols
Confidence Intervals
Substance-Related Disorders
Stomach
Street Drugs
Preoperative Care
Hallucinogens
Amphetamines
Phencyclidine
Postoperative Care
Therapeutics
Cannabis
Cocaine
Counseling
Hospitalization
Body Mass Index

Keywords

  • Abuse
  • Addiction
  • Disorder
  • Gastric band
  • Obese
  • Roux-en-Y gastric bypass
  • Substance use
  • Treatment

ASJC Scopus subject areas

  • Surgery

Cite this

Alcohol and other substance use after bariatric surgery : Prospective evidence from a U.S. multicenter cohort study. / King, Wendy C.; Chen, Jia Yuh; Courcoulas, Anita P.; Dakin, Gregory F.; Engel, Scott G.; Flum, David R.; Hinojosa, Marcelo W.; Kalarchian, Melissa A.; Mattar, Samer; Mitchell, James E.; Pomp, Alfons; Pories, Walter J.; Steffen, Kristine J.; White, Gretchen E.; Wolfe, Bruce; Yanovski, Susan Z.

In: Surgery for Obesity and Related Diseases, 17.01.2017.

Research output: Contribution to journalArticle

King, WC, Chen, JY, Courcoulas, AP, Dakin, GF, Engel, SG, Flum, DR, Hinojosa, MW, Kalarchian, MA, Mattar, S, Mitchell, JE, Pomp, A, Pories, WJ, Steffen, KJ, White, GE, Wolfe, B & Yanovski, SZ 2017, 'Alcohol and other substance use after bariatric surgery: Prospective evidence from a U.S. multicenter cohort study', Surgery for Obesity and Related Diseases. https://doi.org/10.1016/j.soard.2017.03.021
King, Wendy C. ; Chen, Jia Yuh ; Courcoulas, Anita P. ; Dakin, Gregory F. ; Engel, Scott G. ; Flum, David R. ; Hinojosa, Marcelo W. ; Kalarchian, Melissa A. ; Mattar, Samer ; Mitchell, James E. ; Pomp, Alfons ; Pories, Walter J. ; Steffen, Kristine J. ; White, Gretchen E. ; Wolfe, Bruce ; Yanovski, Susan Z. / Alcohol and other substance use after bariatric surgery : Prospective evidence from a U.S. multicenter cohort study. In: Surgery for Obesity and Related Diseases. 2017.
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title = "Alcohol and other substance use after bariatric surgery: Prospective evidence from a U.S. multicenter cohort study",
abstract = "Background: Empirical evidence suggests Roux-en-Y gastric bypass (RYGB) increases risk of developing alcohol use disorder (AUD). However, prospective assessment of substance use disorders (SUD) after bariatric surgery is limited. Objective: To report SUD-related outcomes after RYGB and laparoscopic adjustable gastric banding (LAGB). To identify factors associated with incident SUD-related outcomes. Setting: 10 U.S. hospitals. Methods: The Longitudinal Assessment of Bariatric Surgery-2 is a prospective cohort study. Participants self-reported past-year AUD symptoms (determined by the Alcohol Use Disorders Identification Test), illicit drug use (cocaine, hallucinogens, inhalants, phencyclidine, amphetamines, or marijuana), and SUD treatment (counseling or hospitalization for alcohol or drugs) presurgery and annually postsurgery for up to 7 years through January 2015. Results: Of 2348 participants who underwent RYGB or LAGB, 2003 completed baseline and follow-up assessments (79.2{\%} women, baseline median age: 47 years, median body mass index 45.6). The year-5 cumulative incidence of postsurgery onset AUD symptoms, illicit drug use, and SUD treatment were 20.8{\%} (95{\%} confidence interval (CI): 18.5-23.3), 7.5{\%} (95{\%} CI: 6.1-9.1), and 3.5{\%} (95{\%} CI: 2.6-4.8), respectively, post-RYGB, and 11.3{\%} (95{\%} CI: 8.5-14.9), 4.9{\%} (95{\%} CI: 3.1-7.6), and .9{\%} (95{\%} CI: .4-2.5) post-LAGB. Undergoing RYGB versus LAGB was associated with higher risk of incident AUD symptoms (adjusted hazard ratio or AHR = 2.08 [95{\%} CI: 1.51-2.85]), illicit drug use (AHR = 1.76 [95{\%} CI: 1.07-2.90]) and SUD treatment (AHR = 3.56 [95{\%} CI: 1.26-10.07]). Conclusions: Undergoing RYGB versus LAGB was associated with twice the risk of incident AUD symptoms. One-fifth of participants reported incident AUD symptoms within 5 years post-RYGB. AUD education, screening, evaluation, and treatment referral should be incorporated in pre- and postoperative care.",
keywords = "Abuse, Addiction, Disorder, Gastric band, Obese, Roux-en-Y gastric bypass, Substance use, Treatment",
author = "King, {Wendy C.} and Chen, {Jia Yuh} and Courcoulas, {Anita P.} and Dakin, {Gregory F.} and Engel, {Scott G.} and Flum, {David R.} and Hinojosa, {Marcelo W.} and Kalarchian, {Melissa A.} and Samer Mattar and Mitchell, {James E.} and Alfons Pomp and Pories, {Walter J.} and Steffen, {Kristine J.} and White, {Gretchen E.} and Bruce Wolfe and Yanovski, {Susan Z.}",
year = "2017",
month = "1",
day = "17",
doi = "10.1016/j.soard.2017.03.021",
language = "English (US)",
journal = "Surgery for Obesity and Related Diseases",
issn = "1550-7289",
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TY - JOUR

T1 - Alcohol and other substance use after bariatric surgery

T2 - Prospective evidence from a U.S. multicenter cohort study

AU - King, Wendy C.

AU - Chen, Jia Yuh

AU - Courcoulas, Anita P.

AU - Dakin, Gregory F.

AU - Engel, Scott G.

AU - Flum, David R.

AU - Hinojosa, Marcelo W.

AU - Kalarchian, Melissa A.

AU - Mattar, Samer

AU - Mitchell, James E.

AU - Pomp, Alfons

AU - Pories, Walter J.

AU - Steffen, Kristine J.

AU - White, Gretchen E.

AU - Wolfe, Bruce

AU - Yanovski, Susan Z.

PY - 2017/1/17

Y1 - 2017/1/17

N2 - Background: Empirical evidence suggests Roux-en-Y gastric bypass (RYGB) increases risk of developing alcohol use disorder (AUD). However, prospective assessment of substance use disorders (SUD) after bariatric surgery is limited. Objective: To report SUD-related outcomes after RYGB and laparoscopic adjustable gastric banding (LAGB). To identify factors associated with incident SUD-related outcomes. Setting: 10 U.S. hospitals. Methods: The Longitudinal Assessment of Bariatric Surgery-2 is a prospective cohort study. Participants self-reported past-year AUD symptoms (determined by the Alcohol Use Disorders Identification Test), illicit drug use (cocaine, hallucinogens, inhalants, phencyclidine, amphetamines, or marijuana), and SUD treatment (counseling or hospitalization for alcohol or drugs) presurgery and annually postsurgery for up to 7 years through January 2015. Results: Of 2348 participants who underwent RYGB or LAGB, 2003 completed baseline and follow-up assessments (79.2% women, baseline median age: 47 years, median body mass index 45.6). The year-5 cumulative incidence of postsurgery onset AUD symptoms, illicit drug use, and SUD treatment were 20.8% (95% confidence interval (CI): 18.5-23.3), 7.5% (95% CI: 6.1-9.1), and 3.5% (95% CI: 2.6-4.8), respectively, post-RYGB, and 11.3% (95% CI: 8.5-14.9), 4.9% (95% CI: 3.1-7.6), and .9% (95% CI: .4-2.5) post-LAGB. Undergoing RYGB versus LAGB was associated with higher risk of incident AUD symptoms (adjusted hazard ratio or AHR = 2.08 [95% CI: 1.51-2.85]), illicit drug use (AHR = 1.76 [95% CI: 1.07-2.90]) and SUD treatment (AHR = 3.56 [95% CI: 1.26-10.07]). Conclusions: Undergoing RYGB versus LAGB was associated with twice the risk of incident AUD symptoms. One-fifth of participants reported incident AUD symptoms within 5 years post-RYGB. AUD education, screening, evaluation, and treatment referral should be incorporated in pre- and postoperative care.

AB - Background: Empirical evidence suggests Roux-en-Y gastric bypass (RYGB) increases risk of developing alcohol use disorder (AUD). However, prospective assessment of substance use disorders (SUD) after bariatric surgery is limited. Objective: To report SUD-related outcomes after RYGB and laparoscopic adjustable gastric banding (LAGB). To identify factors associated with incident SUD-related outcomes. Setting: 10 U.S. hospitals. Methods: The Longitudinal Assessment of Bariatric Surgery-2 is a prospective cohort study. Participants self-reported past-year AUD symptoms (determined by the Alcohol Use Disorders Identification Test), illicit drug use (cocaine, hallucinogens, inhalants, phencyclidine, amphetamines, or marijuana), and SUD treatment (counseling or hospitalization for alcohol or drugs) presurgery and annually postsurgery for up to 7 years through January 2015. Results: Of 2348 participants who underwent RYGB or LAGB, 2003 completed baseline and follow-up assessments (79.2% women, baseline median age: 47 years, median body mass index 45.6). The year-5 cumulative incidence of postsurgery onset AUD symptoms, illicit drug use, and SUD treatment were 20.8% (95% confidence interval (CI): 18.5-23.3), 7.5% (95% CI: 6.1-9.1), and 3.5% (95% CI: 2.6-4.8), respectively, post-RYGB, and 11.3% (95% CI: 8.5-14.9), 4.9% (95% CI: 3.1-7.6), and .9% (95% CI: .4-2.5) post-LAGB. Undergoing RYGB versus LAGB was associated with higher risk of incident AUD symptoms (adjusted hazard ratio or AHR = 2.08 [95% CI: 1.51-2.85]), illicit drug use (AHR = 1.76 [95% CI: 1.07-2.90]) and SUD treatment (AHR = 3.56 [95% CI: 1.26-10.07]). Conclusions: Undergoing RYGB versus LAGB was associated with twice the risk of incident AUD symptoms. One-fifth of participants reported incident AUD symptoms within 5 years post-RYGB. AUD education, screening, evaluation, and treatment referral should be incorporated in pre- and postoperative care.

KW - Abuse

KW - Addiction

KW - Disorder

KW - Gastric band

KW - Obese

KW - Roux-en-Y gastric bypass

KW - Substance use

KW - Treatment

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