Alcohol and genetics: New animal models

Kaitlin E. Browman, John C. Crabbe

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

In recent years, it has become increasingly evident that there is a genetic component to alcoholism. Attempts to isolate alcoholism genes have met with modest success, in part because alcoholism is a multigenic trait. Recently, experimental animal models and novel genetic manipulations have provided several clues as to the specific genes involved in alcoholism, and extensive research has identified many genes that might influence responses to alcohol. Although not all of these might be proven to influence drug sensitivity, research has provided evidence for the involvement of a few genes. Ultimately, findings from animal models that investigate the function of specific genes could aid the development of pharmacotherapies to treat alcohol dependence.

Original languageEnglish (US)
Pages (from-to)310-318
Number of pages9
JournalMolecular Medicine Today
Volume5
Issue number7
DOIs
StatePublished - Jul 1 1999

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics

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