Abstract
Alcohol is one of the most widely used chemical substances in our society. Nearly 75% of American adults use alcohol, and 15% of these adults develop lifelong health problems associated with its abuse. Alcohol dependence (alcoholism) is characterized by the development of tolerance (a reduction in the effect of alcohol after single or repeated administration), withdrawal (a state of central nervous system hyperexcitability once alcohol is removed), and a maladaptive pattern of use (loss of control). Why some individuals become alcoholics and others do not has been a question under active investigation by researchers for a number of years. There are clear genetic components to the multidimensional disorder of alcoholism supported by half-sibling and adoption studies.
| Original language | English (US) |
|---|---|
| Title of host publication | Nutrient-Gene Interactions in Health and Disease |
| Publisher | CRC Press |
| Pages | 131-162 |
| Number of pages | 32 |
| ISBN (Electronic) | 9781420039108 |
| ISBN (Print) | 0849322162, 9780849322167 |
| State | Published - Jan 1 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Alcohol and gene expression in the central nervous system. / Reilly, Matthew T.; Fehr, Christopher; Buck, Kari.
Nutrient-Gene Interactions in Health and Disease. CRC Press, 2001. p. 131-162.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Alcohol and gene expression in the central nervous system
AU - Reilly, Matthew T.
AU - Fehr, Christopher
AU - Buck, Kari
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Alcohol is one of the most widely used chemical substances in our society. Nearly 75% of American adults use alcohol, and 15% of these adults develop lifelong health problems associated with its abuse. Alcohol dependence (alcoholism) is characterized by the development of tolerance (a reduction in the effect of alcohol after single or repeated administration), withdrawal (a state of central nervous system hyperexcitability once alcohol is removed), and a maladaptive pattern of use (loss of control). Why some individuals become alcoholics and others do not has been a question under active investigation by researchers for a number of years. There are clear genetic components to the multidimensional disorder of alcoholism supported by half-sibling and adoption studies.
AB - Alcohol is one of the most widely used chemical substances in our society. Nearly 75% of American adults use alcohol, and 15% of these adults develop lifelong health problems associated with its abuse. Alcohol dependence (alcoholism) is characterized by the development of tolerance (a reduction in the effect of alcohol after single or repeated administration), withdrawal (a state of central nervous system hyperexcitability once alcohol is removed), and a maladaptive pattern of use (loss of control). Why some individuals become alcoholics and others do not has been a question under active investigation by researchers for a number of years. There are clear genetic components to the multidimensional disorder of alcoholism supported by half-sibling and adoption studies.
UR - http://www.scopus.com/inward/record.url?scp=0001306728&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0001306728&partnerID=8YFLogxK
M3 - Chapter
SN - 0849322162
SN - 9780849322167
SP - 131
EP - 162
BT - Nutrient-Gene Interactions in Health and Disease
PB - CRC Press
ER -