Alcohol actions on GABAA receptors

From protein structure to mouse behavior

S. Ueno, R. A. Harris, R. O. Messing, A. M. Sanchez-Perez, C. W. Hodge, T. McMahon, D. Wang, K. K. Mehmert, S. P. Kelley, A. Haywood, M. F. Olive, Kari Buck, H. M. Hood, Y. Blednov, G. Findlay, M. P. Mascia

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were R. Adron Harris and Susumu Ueno. The presentations were (1) Protein kinase Cε-regulated sensitivity of γ-aminobutyric acid type A (GABAA) receptors to allosteric agonists, by Robert O. Messing, A. M. Sanchez-Perez, C. W. Hodge, T. McMahon, D. Wang, K. K. Mehmert, S. P. Kelley, A. Haywood, and M. F. Olive; (2) Genetic and functional analysis of a GABAA receptor γ2 subunit variant: A candidate for quantitative trait loci involved in alcohol sensitivity and withdrawal, by Karl J. Buck and Heather M. Hood; (3) Tryptophan-scanning mutagenesis in GABAA receptor subunits: Channel gating and alcohol actions, by Susumu Ueno; and (4) Can a single binding site account for actions of alcohols on GABAA and glycine receptors? by R. Adron Harris, Yuri Blednov, Geoffrey Findlay, and Maria Paola Mascia.

Original languageEnglish (US)
JournalAlcoholism: Clinical and Experimental Research
Volume25
Issue number5 SUPPL.
StatePublished - 2001
Externally publishedYes

Fingerprint

GABA-A Receptors
Alcohols
Proteins
Aminobutyrates
Glycine Receptors
Mutagenesis
Functional analysis
Quantitative Trait Loci
Tryptophan
Protein Kinase C
Japan
Binding Sites
Scanning

Keywords

  • Alcohol Withdrawal
  • GABA
  • Glycine Receptors
  • Protein Kinase C
  • Quantitative Trait Locus

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Ueno, S., Harris, R. A., Messing, R. O., Sanchez-Perez, A. M., Hodge, C. W., McMahon, T., ... Mascia, M. P. (2001). Alcohol actions on GABAA receptors: From protein structure to mouse behavior. Alcoholism: Clinical and Experimental Research, 25(5 SUPPL.).

Alcohol actions on GABAA receptors : From protein structure to mouse behavior. / Ueno, S.; Harris, R. A.; Messing, R. O.; Sanchez-Perez, A. M.; Hodge, C. W.; McMahon, T.; Wang, D.; Mehmert, K. K.; Kelley, S. P.; Haywood, A.; Olive, M. F.; Buck, Kari; Hood, H. M.; Blednov, Y.; Findlay, G.; Mascia, M. P.

In: Alcoholism: Clinical and Experimental Research, Vol. 25, No. 5 SUPPL., 2001.

Research output: Contribution to journalArticle

Ueno, S, Harris, RA, Messing, RO, Sanchez-Perez, AM, Hodge, CW, McMahon, T, Wang, D, Mehmert, KK, Kelley, SP, Haywood, A, Olive, MF, Buck, K, Hood, HM, Blednov, Y, Findlay, G & Mascia, MP 2001, 'Alcohol actions on GABAA receptors: From protein structure to mouse behavior', Alcoholism: Clinical and Experimental Research, vol. 25, no. 5 SUPPL..
Ueno S, Harris RA, Messing RO, Sanchez-Perez AM, Hodge CW, McMahon T et al. Alcohol actions on GABAA receptors: From protein structure to mouse behavior. Alcoholism: Clinical and Experimental Research. 2001;25(5 SUPPL.).
Ueno, S. ; Harris, R. A. ; Messing, R. O. ; Sanchez-Perez, A. M. ; Hodge, C. W. ; McMahon, T. ; Wang, D. ; Mehmert, K. K. ; Kelley, S. P. ; Haywood, A. ; Olive, M. F. ; Buck, Kari ; Hood, H. M. ; Blednov, Y. ; Findlay, G. ; Mascia, M. P. / Alcohol actions on GABAA receptors : From protein structure to mouse behavior. In: Alcoholism: Clinical and Experimental Research. 2001 ; Vol. 25, No. 5 SUPPL.
@article{a78fc773fd664a359762a8b3cfc653cc,
title = "Alcohol actions on GABAA receptors: From protein structure to mouse behavior",
abstract = "This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were R. Adron Harris and Susumu Ueno. The presentations were (1) Protein kinase Cε-regulated sensitivity of γ-aminobutyric acid type A (GABAA) receptors to allosteric agonists, by Robert O. Messing, A. M. Sanchez-Perez, C. W. Hodge, T. McMahon, D. Wang, K. K. Mehmert, S. P. Kelley, A. Haywood, and M. F. Olive; (2) Genetic and functional analysis of a GABAA receptor γ2 subunit variant: A candidate for quantitative trait loci involved in alcohol sensitivity and withdrawal, by Karl J. Buck and Heather M. Hood; (3) Tryptophan-scanning mutagenesis in GABAA receptor subunits: Channel gating and alcohol actions, by Susumu Ueno; and (4) Can a single binding site account for actions of alcohols on GABAA and glycine receptors? by R. Adron Harris, Yuri Blednov, Geoffrey Findlay, and Maria Paola Mascia.",
keywords = "Alcohol Withdrawal, GABA, Glycine Receptors, Protein Kinase C, Quantitative Trait Locus",
author = "S. Ueno and Harris, {R. A.} and Messing, {R. O.} and Sanchez-Perez, {A. M.} and Hodge, {C. W.} and T. McMahon and D. Wang and Mehmert, {K. K.} and Kelley, {S. P.} and A. Haywood and Olive, {M. F.} and Kari Buck and Hood, {H. M.} and Y. Blednov and G. Findlay and Mascia, {M. P.}",
year = "2001",
language = "English (US)",
volume = "25",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "5 SUPPL.",

}

TY - JOUR

T1 - Alcohol actions on GABAA receptors

T2 - From protein structure to mouse behavior

AU - Ueno, S.

AU - Harris, R. A.

AU - Messing, R. O.

AU - Sanchez-Perez, A. M.

AU - Hodge, C. W.

AU - McMahon, T.

AU - Wang, D.

AU - Mehmert, K. K.

AU - Kelley, S. P.

AU - Haywood, A.

AU - Olive, M. F.

AU - Buck, Kari

AU - Hood, H. M.

AU - Blednov, Y.

AU - Findlay, G.

AU - Mascia, M. P.

PY - 2001

Y1 - 2001

N2 - This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were R. Adron Harris and Susumu Ueno. The presentations were (1) Protein kinase Cε-regulated sensitivity of γ-aminobutyric acid type A (GABAA) receptors to allosteric agonists, by Robert O. Messing, A. M. Sanchez-Perez, C. W. Hodge, T. McMahon, D. Wang, K. K. Mehmert, S. P. Kelley, A. Haywood, and M. F. Olive; (2) Genetic and functional analysis of a GABAA receptor γ2 subunit variant: A candidate for quantitative trait loci involved in alcohol sensitivity and withdrawal, by Karl J. Buck and Heather M. Hood; (3) Tryptophan-scanning mutagenesis in GABAA receptor subunits: Channel gating and alcohol actions, by Susumu Ueno; and (4) Can a single binding site account for actions of alcohols on GABAA and glycine receptors? by R. Adron Harris, Yuri Blednov, Geoffrey Findlay, and Maria Paola Mascia.

AB - This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were R. Adron Harris and Susumu Ueno. The presentations were (1) Protein kinase Cε-regulated sensitivity of γ-aminobutyric acid type A (GABAA) receptors to allosteric agonists, by Robert O. Messing, A. M. Sanchez-Perez, C. W. Hodge, T. McMahon, D. Wang, K. K. Mehmert, S. P. Kelley, A. Haywood, and M. F. Olive; (2) Genetic and functional analysis of a GABAA receptor γ2 subunit variant: A candidate for quantitative trait loci involved in alcohol sensitivity and withdrawal, by Karl J. Buck and Heather M. Hood; (3) Tryptophan-scanning mutagenesis in GABAA receptor subunits: Channel gating and alcohol actions, by Susumu Ueno; and (4) Can a single binding site account for actions of alcohols on GABAA and glycine receptors? by R. Adron Harris, Yuri Blednov, Geoffrey Findlay, and Maria Paola Mascia.

KW - Alcohol Withdrawal

KW - GABA

KW - Glycine Receptors

KW - Protein Kinase C

KW - Quantitative Trait Locus

UR - http://www.scopus.com/inward/record.url?scp=17744412210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17744412210&partnerID=8YFLogxK

M3 - Article

VL - 25

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 5 SUPPL.

ER -