Alarin is a vasoactive peptide

Radmila Santic, Sabine M. Schmidhuber, Roland Lang, Isabella Rauch, Elena Voglas, Nicole Eberhard, Johann W. Bauer, Susan D. Brain, Barbara Kofler

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Galanin-like peptide (GALP) is a hypothalamic neuropeptide belonging to the galanin family of peptides. The GALP gene is characterized by extensive differential splicing in a variety of murine tissues. One splice variant excludes exon 3 and results in a frame shift leading to a novel peptide sequence and a stop codon after 49 aa. In this peptide, which we termed alarin, the signal sequence of the GALP precursor peptide and the first 5 aa of the mature GALP are followed by 20 aa without homology to any other murine protein. Alarin mRNA was detected in murine brain, thymus, and skin. In accordance with its vascular localization, the peptide exhibited potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, as was also observed with other members of the galanin peptide family. However, in contrast to galanin peptides in general, the physiological effects of alarin do not appear to be mediated via the known galanin receptors. Alarin adds another facet to the surprisingly high-functional redundancy of the galanin family of peptides.

Original languageEnglish (US)
Pages (from-to)10217-10222
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number24
DOIs
StatePublished - Jun 12 2007

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Keywords

  • Cutaneous microvasculature
  • Galanin-like peptide
  • Plasma extravasation
  • Regulatory peptide
  • Splicing

ASJC Scopus subject areas

  • General

Cite this

Santic, R., Schmidhuber, S. M., Lang, R., Rauch, I., Voglas, E., Eberhard, N., Bauer, J. W., Brain, S. D., & Kofler, B. (2007). Alarin is a vasoactive peptide. Proceedings of the National Academy of Sciences of the United States of America, 104(24), 10217-10222. https://doi.org/10.1073/pnas.0608585104