AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis

Haitao Ji, Zhiyong Ding, David Hawke, Dongming Xing, Bing Hua Jiang, Gordon B. Mills, Zhimin Lu

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Although Niban is highly expressed in human cancer cells, the cellular functions of Niban remain largely unknown. We demonstrate here that ultraviolet irradiation induces phosphorylation of Niban at S602 by AKT, which increases the association of Niban with nucleophosmin and disassociation of nucleophosmin from the MDM2 complex. This leads to the promotion of MDM2-p53 interaction and subsequent p53 degradation, thereby providing an antiapoptotic effect. Conversely, depletion of or deficiency in Niban expression promotes stabilization of p53 with increased cell apoptosis. Our findings illustrate a pivotal role for AKT-mediated phosphorylation of Niban in protecting cells from genotoxic stress-induced cell apoptosis.

Original languageEnglish (US)
Pages (from-to)554-560
Number of pages7
JournalEMBO Reports
Volume13
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

Keywords

  • AKT
  • MDM2
  • Niban
  • apoptosis
  • nucleophosmin
  • p53

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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