AIDS alters the commensal plasma virome

Linlin Li, Xutao Deng, Piyada Linsuwanon, David Bangsberg, Mwebesa Bosco Bwana, Peter Hunt, Jeffrey N. Martin, Steven G. Deeks, Eric Delwart

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

We compared the plasma viromes of HIV-infected subjects with low versus high CD4+ T cell counts from the United States and Uganda by using deep sequencing and detected HIV, hepatitis C virus, hepatitis B virus, GB virus C, anellovirus, and human endogenous retrovirus (HERV) reads. An increase in the proportion of reads for anelloviruses, a family of highly prevalent and genetically diverse human viruses, was seen in subjects with AIDS from both countries. The proportion of endogenous human retrovirus reads was increased in AIDS subjects from Uganda but not the United States. Progression to AIDS is therefore associated with changes in the plasma concentration of commensal viruses.

Original languageEnglish (US)
Pages (from-to)10912-10915
Number of pages4
JournalJournal of virology
Volume87
Issue number19
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Li, L., Deng, X., Linsuwanon, P., Bangsberg, D., Bwana, M. B., Hunt, P., Martin, J. N., Deeks, S. G., & Delwart, E. (2013). AIDS alters the commensal plasma virome. Journal of virology, 87(19), 10912-10915. https://doi.org/10.1128/JVI.01839-13