TY - JOUR
T1 - Aging in male primates
T2 - Reproductive decline, effects of calorie restriction and future research potential
AU - Sitzmann, Brandon D.
AU - Urbanski, Henryk F.
AU - Ottinger, Mary Ann
N1 - Funding Information:
Acknowledgements The authors wish to acknowledge support from the Department of Animal and Avian Sciences, University of Maryland; NIH Grants RR-00163, AG-019914, AG-029612, and the intramural program of the National Institute on Aging, National Institutes of Health.
PY - 2008/9
Y1 - 2008/9
N2 - Although less dramatic than in females, male mammals experience decreasing reproductive function during aging. In primates, multiple facets of the hypothalamic-pituitary-gonadal axis show evidence of gradual age-related decline, including behavioral, neuroendocrine and endocrine alterations such as decreased testosterone levels, reduced circulating dehydroepiandrosterone sulfate (DHEAS) levels, increased numbers of sperm abnormalities, and a general decline in physiological responses. In this review we consider a range of age-related changes in males. These measures, including more subtle aging characteristics, are interesting additional indices for detecting the timing of age-related changes in behavioral, neuroendocrine, and endocrine responses. Evidence of potential effects of calorie restriction as an intervention in reproductive aging is also discussed. A discernable decline occurs in both metabolic and reproductive endocrine processes during male aging. This cascade of events includes neuroendocrine and behavioral changes; biomarkers such as circulating DHEAS also show clear age-related decline. The varied changes that occur during male aging are considered in the context of primate aging in general.
AB - Although less dramatic than in females, male mammals experience decreasing reproductive function during aging. In primates, multiple facets of the hypothalamic-pituitary-gonadal axis show evidence of gradual age-related decline, including behavioral, neuroendocrine and endocrine alterations such as decreased testosterone levels, reduced circulating dehydroepiandrosterone sulfate (DHEAS) levels, increased numbers of sperm abnormalities, and a general decline in physiological responses. In this review we consider a range of age-related changes in males. These measures, including more subtle aging characteristics, are interesting additional indices for detecting the timing of age-related changes in behavioral, neuroendocrine, and endocrine responses. Evidence of potential effects of calorie restriction as an intervention in reproductive aging is also discussed. A discernable decline occurs in both metabolic and reproductive endocrine processes during male aging. This cascade of events includes neuroendocrine and behavioral changes; biomarkers such as circulating DHEAS also show clear age-related decline. The varied changes that occur during male aging are considered in the context of primate aging in general.
KW - Calorie restriction
KW - Male aging
KW - Neuroendocrine systems
KW - Primate
KW - Reproduction
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U2 - 10.1007/s11357-008-9065-0
DO - 10.1007/s11357-008-9065-0
M3 - Review article
C2 - 19424865
AN - SCOPUS:50949084825
SN - 0161-9152
VL - 30
SP - 157
EP - 168
JO - Age
JF - Age
IS - 2-3
ER -