Aggregation in amphiphilic macrocycle-substituted Gd3+ DOTA-type chelates is affected by the regiochemistry of substitution

Benjamin C. Webber; Claudio Cassino; Mauro Botta; Mark Woods

doi:10.1021/ic5028724

Aggregation in amphiphilic macrocycle-substituted Gd³⁺ DOTA-type chelates is affected by the regiochemistry of substitution

Benjamin C. Webber, Claudio Cassino, Mauro Botta, Mark Woods

Advanced Imaging Research Center

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Gd³⁺ chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.

Original language	English (US)
Pages (from-to)	2085-2087
Number of pages	3
Journal	Inorganic Chemistry
Volume	54
Issue number	5
DOIs	https://doi.org/10.1021/ic5028724
State	Published - Mar 2 2015

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry

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10.1021/ic5028724

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abstract = "Gd3+ chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.",

author = "Webber, {Benjamin C.} and Claudio Cassino and Mauro Botta and Mark Woods",

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AU - Cassino, Claudio

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AU - Woods, Mark

PY - 2015/3/2

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N2 - Gd3+ chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.

AB - Gd3+ chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.

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Aggregation in amphiphilic macrocycle-substituted Gd³⁺ DOTA-type chelates is affected by the regiochemistry of substitution

Abstract

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