Aggregation in amphiphilic macrocycle-substituted Gd3+ DOTA-type chelates is affected by the regiochemistry of substitution

Benjamin C. Webber, Claudio Cassino, Mauro Botta, Mark Woods

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Gd3+ chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.

Original languageEnglish (US)
Pages (from-to)2085-2087
Number of pages3
JournalInorganic Chemistry
Volume54
Issue number5
DOIs
StatePublished - Mar 2 2015

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Chelating Agents
chelates
Isomers
Contrast Media
Substitution reactions
Agglomeration
isomers
Magnetic Resonance Imaging
substitutes
Barreling
Magnetic resonance
Self assembly
magnetic resonance
self assembly
Imaging techniques
diphenyl

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Medicine(all)

Cite this

Aggregation in amphiphilic macrocycle-substituted Gd3+ DOTA-type chelates is affected by the regiochemistry of substitution. / Webber, Benjamin C.; Cassino, Claudio; Botta, Mauro; Woods, Mark.

In: Inorganic Chemistry, Vol. 54, No. 5, 02.03.2015, p. 2085-2087.

Research output: Contribution to journalArticle

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