Agency for healthcare research and quality evidence-based practice center methods for systematically reviewing complex multicomponent health care interventions

Jeanne Marie Guise, Christine Chang, Meera Viswanathan, Susan Glick, Jonathan Treadwell, Craig A. Umscheid, Evelyn Whitlock, Rongwei Fu, Elise Berliner, Robin Paynter, Johanna Anderson, Pua Motu'Apuaka, Tom Trikalinos

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Objectives The purpose of this Agency for Healthcare Research and Quality Evidence-based Practice Center methods white paper was to outline approaches to conducting systematic reviews of complex multicomponent health care interventions.

Study Design and Setting We performed a literature scan and conducted semistructured interviews with international experts who conduct research or systematic reviews of complex multicomponent interventions (CMCIs) or organizational leaders who implement CMCIs in health care.

Results Challenges identified include lack of consistent terminology for such interventions (eg, complex, multicomponent, multidimensional, multifactorial); a wide range of approaches used to frame the review, from grouping interventions by common features to using more theoretical approaches; decisions regarding whether and how to quantitatively analyze the interventions, from holistic to individual component analytic approaches; and incomplete and inconsistent reporting of elements critical to understanding the success and impact of multicomponent interventions, such as methods used for implementation the context in which interventions are implemented.

Conclusion We provide a framework for the spectrum of conceptual and analytic approaches to synthesizing studies of multicomponent interventions and an initial list of critical reporting elements for such studies. This information is intended to help systematic reviewers understand the options and tradeoffs available for such reviews.

Original languageEnglish (US)
Pages (from-to)1181-1191
Number of pages11
JournalJournal of Clinical Epidemiology
Volume67
Issue number11
DOIs
StatePublished - Nov 1 2014

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Keywords

  • Complex interventions
  • Complexity
  • Evidence synthesis methods
  • Evidence-based medicine
  • Multicomponent interventions
  • Reporting guideline
  • Systematic reviews

ASJC Scopus subject areas

  • Epidemiology

Cite this

Guise, J. M., Chang, C., Viswanathan, M., Glick, S., Treadwell, J., Umscheid, C. A., Whitlock, E., Fu, R., Berliner, E., Paynter, R., Anderson, J., Motu'Apuaka, P., & Trikalinos, T. (2014). Agency for healthcare research and quality evidence-based practice center methods for systematically reviewing complex multicomponent health care interventions. Journal of Clinical Epidemiology, 67(11), 1181-1191. https://doi.org/10.1016/j.jclinepi.2014.06.010