Age-specific serum anti-Müllerian hormone values for 17,120 women presenting to fertility centers within the United States

David B. Seifer, Valerie L. Baker, Benjamin Leader

Research output: Contribution to journalArticle

173 Scopus citations

Abstract

Objective: To determine age-specific serum anti-Müllerian hormone (AMH) values for women presenting to U.S. fertility clinics. Design: Retrospective study. Setting: Single clinical reference laboratory. Patient(s): A total of 17,120 women of reproductive age ranging from 24 to 50 years old. Intervention(s): None. Main Outcome Measure(s): Determination of single-year median and mean AMH values with SDs. Result(s): Single-year-specific median, mean, and SD values are summarized in Table 1. Both median and mean AMH values decreased steadily in a manner highly correlated with advancing age. The average yearly decrease in the median serum AMH value was 0.2 ng/mL/year through age 35 and then diminished to 0.1 ng/mL/year after age 35. The rate of decline in mean AMH values was 0.2 ng/mL/year through age 40 and then diminished to 0.1 ng/mL/year thereafter. Conclusion(s): Median and mean AMH levels decreased steadily with increasing age from 24 to 50 years of age. Such data may be of value to physicians and their patients who are considering reproductive options.

Original languageEnglish (US)
Pages (from-to)747-750
Number of pages4
JournalFertility and sterility
Volume95
Issue number2
DOIs
StatePublished - Feb 1 2011

Keywords

  • AMH
  • Anti-Müllerian hormone
  • MIS
  • Müllerian inhibiting substance
  • age-specific values
  • ovarian aging
  • ovarian reserve
  • reference values
  • reproductive aging

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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