Age-specific prevalence, incidence, and duration of human papillomavirus infections in a cohort of 290 US men

Anna R. Giuliano, Beibei Lu, Carrie Nielson, Roberto Flores, Mary R. Papenfuss, Ji Hyun Lee, Martha Abrahamsen, Robin B. Harris

Research output: Contribution to journalArticle

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Abstract

Background. Human papillomavirus (HPV) infections cause disease in men and women, and male-to-female HPVtransmission influences the risk of cancer in females. The purpose of the present study was to describe the overall and age-specific incidence and clearance of HPV infections in men. Methods. In a prospective cohort study of 290 men aged 18-44 years, participants were examined at baseline and every 6 months, with a mean duration of follow-up of 15.5 months. Results. The period prevalence was 52.8% for any, 31.7% for oncogenic, and 30.0% for nononcogenic HPV infection. The 12-month cumulative risk of acquiring a new HPV infection was 29.2%. Incidences of HPV types 6, 11, 16, and 18 were 2.8, 0.5, 4.8, and 0.8 per 1000 person-months, respectively. The median time to clearance of any HPV infection was 5.9 months (95% confidence interval, 5.7- 6.1 months), with comparable times to clearance for oncogenic and nononcogenic infections. Approximately 75% of men tested negative for any HPV 12 months after initial HPV detection. Age was not significantly associated with HPV incidence or duration of infection in men. Conclusion. HPV infection in men was common, with relatively rapid rates of acquisition and clearance.

Original languageEnglish (US)
Pages (from-to)827-835
Number of pages9
JournalJournal of Infectious Diseases
Volume198
Issue number6
DOIs
StatePublished - Sep 15 2008

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Papillomavirus Infections
Incidence
Human papillomavirus 11
Human papillomavirus 6
Infection
Cohort Studies
Prospective Studies
Confidence Intervals

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Age-specific prevalence, incidence, and duration of human papillomavirus infections in a cohort of 290 US men. / Giuliano, Anna R.; Lu, Beibei; Nielson, Carrie; Flores, Roberto; Papenfuss, Mary R.; Lee, Ji Hyun; Abrahamsen, Martha; Harris, Robin B.

In: Journal of Infectious Diseases, Vol. 198, No. 6, 15.09.2008, p. 827-835.

Research output: Contribution to journalArticle

Giuliano, AR, Lu, B, Nielson, C, Flores, R, Papenfuss, MR, Lee, JH, Abrahamsen, M & Harris, RB 2008, 'Age-specific prevalence, incidence, and duration of human papillomavirus infections in a cohort of 290 US men', Journal of Infectious Diseases, vol. 198, no. 6, pp. 827-835. https://doi.org/10.1086/591095
Giuliano, Anna R. ; Lu, Beibei ; Nielson, Carrie ; Flores, Roberto ; Papenfuss, Mary R. ; Lee, Ji Hyun ; Abrahamsen, Martha ; Harris, Robin B. / Age-specific prevalence, incidence, and duration of human papillomavirus infections in a cohort of 290 US men. In: Journal of Infectious Diseases. 2008 ; Vol. 198, No. 6. pp. 827-835.
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