Age related optic nerve axonal loss in adult Brown Norway rats

William O. Cepurna, Robert J. Kayton, Elaine Johnson, John Morrison

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The effect of age on the number and morphology of optic nerve axons in adult Brown Norway rats (5-31 months old) (n=29) was examined using transmission electron microscopy (TEM). By manually counting every axon in areas representing 60% of the optic nerve cross-section, we found a significant negative correlation between age and axon count (R2=0·18, P2=0·79, P

Original languageEnglish (US)
Pages (from-to)877-884
Number of pages8
JournalExperimental Eye Research
Volume80
Issue number6
DOIs
StatePublished - Jun 2005

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Optic Nerve
Axons
Transmission Electron Microscopy

Keywords

  • Aging
  • Axonal transport
  • Axons
  • Glaucoma
  • Neurodegenerative diseases
  • Optic nerve

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Age related optic nerve axonal loss in adult Brown Norway rats. / Cepurna, William O.; Kayton, Robert J.; Johnson, Elaine; Morrison, John.

In: Experimental Eye Research, Vol. 80, No. 6, 06.2005, p. 877-884.

Research output: Contribution to journalArticle

Cepurna, William O. ; Kayton, Robert J. ; Johnson, Elaine ; Morrison, John. / Age related optic nerve axonal loss in adult Brown Norway rats. In: Experimental Eye Research. 2005 ; Vol. 80, No. 6. pp. 877-884.
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