Age-related changes in prefrontal white matter volume across adolescence

Bonnie J. Nagel, Krista Lisdahl Medina, June Yoshii, Alecia D. Schweinsburg, Ida Moadab, Susan F. Tapert

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Past research has suggested that white matter volume increases from childhood to adulthood; however, during adolescence, there is somewhat limited data to support this finding. In the present study, 65 typically developing adolescents underwent structural magnetic resonance imaging. Using magnetic resonance imaging, prefrontal white matter volumes were examined in relation to adolescent age and sex. Surprisingly, results suggested that prefrontal white matter volume decreased during late adolescence, particularly among the female sex. These findings are inconsistent with past research and suggest that perhaps some developmental processes in late adolescence are not yet fully explained. Possible methodological contributions and implications for the current findings are discussed.

Original languageEnglish (US)
Pages (from-to)1427-1431
Number of pages5
Issue number13
StatePublished - Sep 2006


  • Adolescent development
  • Frontal lobes
  • Magnetic resonance imaging
  • Segmentation
  • White matter

ASJC Scopus subject areas

  • Neuroscience(all)


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