Age-related changes in cochlear blood flow response to occlusion of anterior inferior cerebellar artery in mice

Toru Suzuki, Alfred Nuttall, Tianying Ren, Josef M. Miller

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Previous studies suggest that autoregulation of cochlear blood flow (CBF) may be impaired by aging. In this study, we quantified the capacity of CBF autoregulation in young adult (6-month-old) and aged (21-month-old) CBA mice, to examine the effect of aging on CBF autoregulation. The technique of anterior inferior cerebellar artery (AICA) occlusion was employed to manipulate cochlear perfusion pressure. The CBF was measured by laser Doppler flowmetry during intermittent occlusion of the AICA with a microvascular clamp, which causes an initial decrease in CBF. The autoregulation of CBF was evaluated by quantifying the CBF increase (compensatory dilatory response in the cochlear vessels) during AICA occlusion. Our results demonstrated that autoregulation of CBF was significantly reduced and that collateral vascular function supplying CBF was significantly lower in the aged group. These findings suggest that the aged ear has less capacity to maintain stable blood flow and thus may be more vulnerable to stress factors that affect cochlear function.

Original languageEnglish (US)
Pages (from-to)648-653
Number of pages6
JournalAnnals of Otology, Rhinology and Laryngology
Volume107
Issue number8
StatePublished - 1998

Fingerprint

Cochlea
Arteries
Homeostasis
Inbred CBA Mouse
Laser-Doppler Flowmetry
Ear
Blood Vessels
Young Adult
Perfusion

Keywords

  • Autoregulation
  • Collateral vascular function
  • Laser Doppler flowmetry
  • Presbycusis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Age-related changes in cochlear blood flow response to occlusion of anterior inferior cerebellar artery in mice. / Suzuki, Toru; Nuttall, Alfred; Ren, Tianying; Miller, Josef M.

In: Annals of Otology, Rhinology and Laryngology, Vol. 107, No. 8, 1998, p. 648-653.

Research output: Contribution to journalArticle

@article{f1c964d5405846caa76f904ef9ccc164,
title = "Age-related changes in cochlear blood flow response to occlusion of anterior inferior cerebellar artery in mice",
abstract = "Previous studies suggest that autoregulation of cochlear blood flow (CBF) may be impaired by aging. In this study, we quantified the capacity of CBF autoregulation in young adult (6-month-old) and aged (21-month-old) CBA mice, to examine the effect of aging on CBF autoregulation. The technique of anterior inferior cerebellar artery (AICA) occlusion was employed to manipulate cochlear perfusion pressure. The CBF was measured by laser Doppler flowmetry during intermittent occlusion of the AICA with a microvascular clamp, which causes an initial decrease in CBF. The autoregulation of CBF was evaluated by quantifying the CBF increase (compensatory dilatory response in the cochlear vessels) during AICA occlusion. Our results demonstrated that autoregulation of CBF was significantly reduced and that collateral vascular function supplying CBF was significantly lower in the aged group. These findings suggest that the aged ear has less capacity to maintain stable blood flow and thus may be more vulnerable to stress factors that affect cochlear function.",
keywords = "Autoregulation, Collateral vascular function, Laser Doppler flowmetry, Presbycusis",
author = "Toru Suzuki and Alfred Nuttall and Tianying Ren and Miller, {Josef M.}",
year = "1998",
language = "English (US)",
volume = "107",
pages = "648--653",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Company",
number = "8",

}

TY - JOUR

T1 - Age-related changes in cochlear blood flow response to occlusion of anterior inferior cerebellar artery in mice

AU - Suzuki, Toru

AU - Nuttall, Alfred

AU - Ren, Tianying

AU - Miller, Josef M.

PY - 1998

Y1 - 1998

N2 - Previous studies suggest that autoregulation of cochlear blood flow (CBF) may be impaired by aging. In this study, we quantified the capacity of CBF autoregulation in young adult (6-month-old) and aged (21-month-old) CBA mice, to examine the effect of aging on CBF autoregulation. The technique of anterior inferior cerebellar artery (AICA) occlusion was employed to manipulate cochlear perfusion pressure. The CBF was measured by laser Doppler flowmetry during intermittent occlusion of the AICA with a microvascular clamp, which causes an initial decrease in CBF. The autoregulation of CBF was evaluated by quantifying the CBF increase (compensatory dilatory response in the cochlear vessels) during AICA occlusion. Our results demonstrated that autoregulation of CBF was significantly reduced and that collateral vascular function supplying CBF was significantly lower in the aged group. These findings suggest that the aged ear has less capacity to maintain stable blood flow and thus may be more vulnerable to stress factors that affect cochlear function.

AB - Previous studies suggest that autoregulation of cochlear blood flow (CBF) may be impaired by aging. In this study, we quantified the capacity of CBF autoregulation in young adult (6-month-old) and aged (21-month-old) CBA mice, to examine the effect of aging on CBF autoregulation. The technique of anterior inferior cerebellar artery (AICA) occlusion was employed to manipulate cochlear perfusion pressure. The CBF was measured by laser Doppler flowmetry during intermittent occlusion of the AICA with a microvascular clamp, which causes an initial decrease in CBF. The autoregulation of CBF was evaluated by quantifying the CBF increase (compensatory dilatory response in the cochlear vessels) during AICA occlusion. Our results demonstrated that autoregulation of CBF was significantly reduced and that collateral vascular function supplying CBF was significantly lower in the aged group. These findings suggest that the aged ear has less capacity to maintain stable blood flow and thus may be more vulnerable to stress factors that affect cochlear function.

KW - Autoregulation

KW - Collateral vascular function

KW - Laser Doppler flowmetry

KW - Presbycusis

UR - http://www.scopus.com/inward/record.url?scp=7344262555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7344262555&partnerID=8YFLogxK

M3 - Article

C2 - 9716864

AN - SCOPUS:7344262555

VL - 107

SP - 648

EP - 653

JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

IS - 8

ER -