Age-related cerebrovascular response to global ischemia in pigs

Jeffrey Kirsch, M. A. Helfaer, K. Blizzard, T. J K Toung, R. J. Traystman

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We tested the hypothesis that 1- to 2-wk-old pigs (piglet) have improved recovery of cerebral blood flow (CBF), cerebral oxygen consumption (CMRO2), and somatosensory-evoked potentials (SEP) compared with 6- to 8-mo-old pigs (pig) after transient global cerebral ischemia. All animals were anesthetized with pentobarbital sodium. After tracheostomy ventilation was adjusted to maintain normoxia (arterial oxygen pressure, 100-150 mmHg) and normocarbia (arterial carbon dioxide pressure, 35-40 mmHg). Arterial blood gases, blood pressure, and hemoglobin concentration remained within physiological limits throughout the experiment. Cerebral ischemia was produced by sequentially tightening ligatures around the inferior vena cava and ascending aorta. During ischemia the electroencephalogram and SEP became isoelectric within 40 and 120 s, respectively. At 10 min of reperfusion hyperemia occurred in most brain regions (e.g., whole brain: piglet, 270 ± 45%; pig, 316 ± 48%). In pigs delayed hypoperfusion occurred in all regions except white matter. In contrast, piglets only had delayed hyperperfusion to the brain stem and caudate nucleus. Throughout reperfusion CMRO2 was decreased in pigs (3.3 ± 0.4 to 1.9 ± 0.2 ml·min-1·100 g-1) but was not different from control (2.7 ± 0.3 ml·min-1·100 g-1) in piglets. By the end of reperfusion SEP amplitude was closer to control in piglets than pigs (55 ± 9 vs. 32 ± 4% of control). We conclude that 1- to 2-wk-old piglets have quicker return of CBF, CMRO2, and SEP to control values after global ischemia, which mechanistically may explain previous reports of improved neurological recovery in young animals after transient ischemia.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume259
Issue number5 28-5
StatePublished - 1990
Externally publishedYes

Fingerprint

Somatosensory Evoked Potentials
Swine
Ischemia
Cerebrovascular Circulation
Reperfusion
Caudate Nucleus
Tracheostomy
Transient Ischemic Attack
Hyperemia
Brain
Inferior Vena Cava
Pentobarbital
Brain Ischemia
Carbon Dioxide
Oxygen Consumption
Brain Stem
Ligation
Aorta
Electroencephalography
Arterial Pressure

Keywords

  • Cerebral blood flow
  • Cerebral ischemia
  • Cerebral metabolism
  • Evoked potentials

ASJC Scopus subject areas

  • Physiology

Cite this

Kirsch, J., Helfaer, M. A., Blizzard, K., Toung, T. J. K., & Traystman, R. J. (1990). Age-related cerebrovascular response to global ischemia in pigs. American Journal of Physiology - Heart and Circulatory Physiology, 259(5 28-5).

Age-related cerebrovascular response to global ischemia in pigs. / Kirsch, Jeffrey; Helfaer, M. A.; Blizzard, K.; Toung, T. J K; Traystman, R. J.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 259, No. 5 28-5, 1990.

Research output: Contribution to journalArticle

Kirsch, Jeffrey ; Helfaer, M. A. ; Blizzard, K. ; Toung, T. J K ; Traystman, R. J. / Age-related cerebrovascular response to global ischemia in pigs. In: American Journal of Physiology - Heart and Circulatory Physiology. 1990 ; Vol. 259, No. 5 28-5.
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