Abstract
Objective: The objective of this study is to assess variation in detection and false positive rates and adverse pregnancy outcomes across different age groups when a one-size-fits-all risk-cutoff value, such as 1/270, is used in integrated screening for Down syndrome. Method: A Monte Carlo simulation was utilized to estimate the detection and false positive rates as well as adverse pregnancy outcomes. Results: Using a one-size-fits-all risk-cutoff value, such as 1/270, can result in considerably high variations in detection and false positive rates across maternal ages and lead to a higher than the minimum possible total number of adverse outcomes. Conclusion: Our findings indicate that the one-size-fits-all risk-cutoff value of 1/270, commonly used in DS screening, should be revisited and alternative (possibly age-based) cutoff values and strategies should be considered.
Original language | English (US) |
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Pages (from-to) | 894-898 |
Number of pages | 5 |
Journal | Prenatal Diagnosis |
Volume | 37 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2017 |
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Genetics(clinical)