Age associated decrements in dopamine D2 receptors in thalamus and in temporal insula of human subjects

Gene Jack Wang; Nora D. Volkow; Joanna S. Fowler; Jean Logan; Ruben Gur; Noelwah Netusil; Robert J. Hitzemann; Naomi S. Pappas

doi:10.1016/0024-3205(96)00262-7

Age associated decrements in dopamine D₂ receptors in thalamus and in temporal insula of human subjects

Gene Jack Wang, Nora D. Volkow, Joanna S. Fowler, Jean Logan, Ruben Gur, Noelwah Netusil, Robert J. Hitzemann, Naomi S. Pappas

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

This study evaluates the effects of age on DA D₂ receptors in extrastriatal regions. DA D₂ receptor availability was evaluated in 42 healthy male subjects (mean age 41±16, range 21 - 86 year old) with positron emission tomography (PET) and [¹¹C]raclopride. Estimates of B(max.)/K(d) were obtained using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that in cerebellum. Correlations between age and D₂ receptors were significant in putamen (r = -0.58, p ≤ 0.0001), caudate (r = -0.54, p ≤ 0.0002), thalamus (r = -0.33, p ≤ 0.03) and temporal insula (r = -0.39, p ≤ 0.01) but not in any of the frontal regions. The decrease in DA D₂ receptor availability was 6.6% per decade in caudate, 8.2% in putamen, 7.6% in thalamus and 13% in temporal insula. This study indicates that D₂ losses with age are not limited to striatum and involve also thalamic as well as temporal cortical regions.

Original language	English (US)
Pages (from-to)	PL31-PL35
Journal	Life Sciences
Volume	59
Issue number	1
DOIs	https://doi.org/10.1016/0024-3205(96)00262-7
State	Published - May 31 1996
Externally published	Yes

Keywords

[C]raclopride
aging
extrastriatal dopamine receptors
positron emission tomography

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/0024-3205(96)00262-7

Cite this

@article{5d9380b975734db89f1bef4e52e41e77,

title = "Age associated decrements in dopamine D2 receptors in thalamus and in temporal insula of human subjects",

abstract = "This study evaluates the effects of age on DA D2 receptors in extrastriatal regions. DA D2 receptor availability was evaluated in 42 healthy male subjects (mean age 41±16, range 21 - 86 year old) with positron emission tomography (PET) and [11C]raclopride. Estimates of B(max.)/K(d) were obtained using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that in cerebellum. Correlations between age and D2 receptors were significant in putamen (r = -0.58, p ≤ 0.0001), caudate (r = -0.54, p ≤ 0.0002), thalamus (r = -0.33, p ≤ 0.03) and temporal insula (r = -0.39, p ≤ 0.01) but not in any of the frontal regions. The decrease in DA D2 receptor availability was 6.6% per decade in caudate, 8.2% in putamen, 7.6% in thalamus and 13% in temporal insula. This study indicates that D2 losses with age are not limited to striatum and involve also thalamic as well as temporal cortical regions.",

keywords = "[C]raclopride, aging, extrastriatal dopamine receptors, positron emission tomography",

author = "Wang, {Gene Jack} and Volkow, {Nora D.} and Fowler, {Joanna S.} and Jean Logan and Ruben Gur and Noelwah Netusil and Hitzemann, {Robert J.} and Pappas, {Naomi S.}",

note = "Funding Information: This work was supportedb y NIDA Grant No. R01 - DA06891 and by U.S. Departmento f Energy under contract DE-ACO2-76CHOOO16. The authors thank D. Alexoff, R. Carciello, P. King, A. Levy, R. MacGregor, C. Redvanly, D. Schlyer. C. Shea, D. Warner, C. Wong for their participationi n various aspectso f this work.",

year = "1996",

month = may,

day = "31",

doi = "10.1016/0024-3205(96)00262-7",

language = "English (US)",

volume = "59",

pages = "PL31--PL35",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "1",

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TY - JOUR

T1 - Age associated decrements in dopamine D2 receptors in thalamus and in temporal insula of human subjects

AU - Wang, Gene Jack

AU - Volkow, Nora D.

AU - Fowler, Joanna S.

AU - Logan, Jean

AU - Gur, Ruben

AU - Netusil, Noelwah

AU - Hitzemann, Robert J.

AU - Pappas, Naomi S.

N1 - Funding Information: This work was supportedb y NIDA Grant No. R01 - DA06891 and by U.S. Departmento f Energy under contract DE-ACO2-76CHOOO16. The authors thank D. Alexoff, R. Carciello, P. King, A. Levy, R. MacGregor, C. Redvanly, D. Schlyer. C. Shea, D. Warner, C. Wong for their participationi n various aspectso f this work.

PY - 1996/5/31

Y1 - 1996/5/31

N2 - This study evaluates the effects of age on DA D2 receptors in extrastriatal regions. DA D2 receptor availability was evaluated in 42 healthy male subjects (mean age 41±16, range 21 - 86 year old) with positron emission tomography (PET) and [11C]raclopride. Estimates of B(max.)/K(d) were obtained using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that in cerebellum. Correlations between age and D2 receptors were significant in putamen (r = -0.58, p ≤ 0.0001), caudate (r = -0.54, p ≤ 0.0002), thalamus (r = -0.33, p ≤ 0.03) and temporal insula (r = -0.39, p ≤ 0.01) but not in any of the frontal regions. The decrease in DA D2 receptor availability was 6.6% per decade in caudate, 8.2% in putamen, 7.6% in thalamus and 13% in temporal insula. This study indicates that D2 losses with age are not limited to striatum and involve also thalamic as well as temporal cortical regions.

AB - This study evaluates the effects of age on DA D2 receptors in extrastriatal regions. DA D2 receptor availability was evaluated in 42 healthy male subjects (mean age 41±16, range 21 - 86 year old) with positron emission tomography (PET) and [11C]raclopride. Estimates of B(max.)/K(d) were obtained using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that in cerebellum. Correlations between age and D2 receptors were significant in putamen (r = -0.58, p ≤ 0.0001), caudate (r = -0.54, p ≤ 0.0002), thalamus (r = -0.33, p ≤ 0.03) and temporal insula (r = -0.39, p ≤ 0.01) but not in any of the frontal regions. The decrease in DA D2 receptor availability was 6.6% per decade in caudate, 8.2% in putamen, 7.6% in thalamus and 13% in temporal insula. This study indicates that D2 losses with age are not limited to striatum and involve also thalamic as well as temporal cortical regions.

KW - [C]raclopride

KW - aging

KW - extrastriatal dopamine receptors

KW - positron emission tomography

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U2 - 10.1016/0024-3205(96)00262-7

DO - 10.1016/0024-3205(96)00262-7

M3 - Article

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AN - SCOPUS:0343371815

SN - 0024-3205

VL - 59

SP - PL31-PL35

JO - Life Sciences

JF - Life Sciences

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