TY - JOUR
T1 - Age associated decrements in dopamine D2 receptors in thalamus and in temporal insula of human subjects
AU - Wang, Gene Jack
AU - Volkow, Nora D.
AU - Fowler, Joanna S.
AU - Logan, Jean
AU - Gur, Ruben
AU - Netusil, Noelwah
AU - Hitzemann, Robert J.
AU - Pappas, Naomi S.
N1 - Funding Information:
This work was supportedb y NIDA Grant No. R01 - DA06891 and by U.S. Departmento f Energy under contract DE-ACO2-76CHOOO16. The authors thank D. Alexoff, R. Carciello, P. King, A. Levy, R. MacGregor, C. Redvanly, D. Schlyer. C. Shea, D. Warner, C. Wong for their participationi n various aspectso f this work.
PY - 1996/5/31
Y1 - 1996/5/31
N2 - This study evaluates the effects of age on DA D2 receptors in extrastriatal regions. DA D2 receptor availability was evaluated in 42 healthy male subjects (mean age 41±16, range 21 - 86 year old) with positron emission tomography (PET) and [11C]raclopride. Estimates of B(max.)/K(d) were obtained using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that in cerebellum. Correlations between age and D2 receptors were significant in putamen (r = -0.58, p ≤ 0.0001), caudate (r = -0.54, p ≤ 0.0002), thalamus (r = -0.33, p ≤ 0.03) and temporal insula (r = -0.39, p ≤ 0.01) but not in any of the frontal regions. The decrease in DA D2 receptor availability was 6.6% per decade in caudate, 8.2% in putamen, 7.6% in thalamus and 13% in temporal insula. This study indicates that D2 losses with age are not limited to striatum and involve also thalamic as well as temporal cortical regions.
AB - This study evaluates the effects of age on DA D2 receptors in extrastriatal regions. DA D2 receptor availability was evaluated in 42 healthy male subjects (mean age 41±16, range 21 - 86 year old) with positron emission tomography (PET) and [11C]raclopride. Estimates of B(max.)/K(d) were obtained using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that in cerebellum. Correlations between age and D2 receptors were significant in putamen (r = -0.58, p ≤ 0.0001), caudate (r = -0.54, p ≤ 0.0002), thalamus (r = -0.33, p ≤ 0.03) and temporal insula (r = -0.39, p ≤ 0.01) but not in any of the frontal regions. The decrease in DA D2 receptor availability was 6.6% per decade in caudate, 8.2% in putamen, 7.6% in thalamus and 13% in temporal insula. This study indicates that D2 losses with age are not limited to striatum and involve also thalamic as well as temporal cortical regions.
KW - [C]raclopride
KW - aging
KW - extrastriatal dopamine receptors
KW - positron emission tomography
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U2 - 10.1016/0024-3205(96)00262-7
DO - 10.1016/0024-3205(96)00262-7
M3 - Article
C2 - 8684263
AN - SCOPUS:0343371815
SN - 0024-3205
VL - 59
SP - PL31-PL35
JO - Life Sciences
JF - Life Sciences
IS - 1
ER -