Age associated decrements in dopamine D2 receptors in thalamus and in temporal insula of human subjects

Gene Jack Wang, Nora D. Volkow, Joanna S. Fowler, Jean Logan, Ruben Gur, Noelwah Netusil, Robert Hitzemann, Naomi S. Pappas

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

This study evaluates the effects of age on DA D2 receptors in extrastriatal regions. DA D2 receptor availability was evaluated in 42 healthy male subjects (mean age 41±16, range 21 - 86 year old) with positron emission tomography (PET) and [11C]raclopride. Estimates of B(max.)/K(d) were obtained using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that in cerebellum. Correlations between age and D2 receptors were significant in putamen (r = -0.58, p ≤ 0.0001), caudate (r = -0.54, p ≤ 0.0002), thalamus (r = -0.33, p ≤ 0.03) and temporal insula (r = -0.39, p ≤ 0.01) but not in any of the frontal regions. The decrease in DA D2 receptor availability was 6.6% per decade in caudate, 8.2% in putamen, 7.6% in thalamus and 13% in temporal insula. This study indicates that D2 losses with age are not limited to striatum and involve also thalamic as well as temporal cortical regions.

Original languageEnglish (US)
JournalLife Sciences
Volume59
Issue number1
DOIs
StatePublished - May 31 1996
Externally publishedYes

Fingerprint

Dopamine D2 Receptors
Putamen
Thalamus
Availability
Temporal Lobe
Raclopride
Positron emission tomography
Occipital Lobe
Gyrus Cinguli
Frontal Lobe
Prefrontal Cortex
Positron-Emission Tomography
Cerebellum
Healthy Volunteers

Keywords

  • [C]raclopride
  • aging
  • extrastriatal dopamine receptors
  • positron emission tomography

ASJC Scopus subject areas

  • Pharmacology

Cite this

Wang, G. J., Volkow, N. D., Fowler, J. S., Logan, J., Gur, R., Netusil, N., ... Pappas, N. S. (1996). Age associated decrements in dopamine D2 receptors in thalamus and in temporal insula of human subjects. Life Sciences, 59(1). https://doi.org/10.1016/0024-3205(96)00262-7

Age associated decrements in dopamine D2 receptors in thalamus and in temporal insula of human subjects. / Wang, Gene Jack; Volkow, Nora D.; Fowler, Joanna S.; Logan, Jean; Gur, Ruben; Netusil, Noelwah; Hitzemann, Robert; Pappas, Naomi S.

In: Life Sciences, Vol. 59, No. 1, 31.05.1996.

Research output: Contribution to journalArticle

Wang, Gene Jack ; Volkow, Nora D. ; Fowler, Joanna S. ; Logan, Jean ; Gur, Ruben ; Netusil, Noelwah ; Hitzemann, Robert ; Pappas, Naomi S. / Age associated decrements in dopamine D2 receptors in thalamus and in temporal insula of human subjects. In: Life Sciences. 1996 ; Vol. 59, No. 1.
@article{5d9380b975734db89f1bef4e52e41e77,
title = "Age associated decrements in dopamine D2 receptors in thalamus and in temporal insula of human subjects",
abstract = "This study evaluates the effects of age on DA D2 receptors in extrastriatal regions. DA D2 receptor availability was evaluated in 42 healthy male subjects (mean age 41±16, range 21 - 86 year old) with positron emission tomography (PET) and [11C]raclopride. Estimates of B(max.)/K(d) were obtained using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that in cerebellum. Correlations between age and D2 receptors were significant in putamen (r = -0.58, p ≤ 0.0001), caudate (r = -0.54, p ≤ 0.0002), thalamus (r = -0.33, p ≤ 0.03) and temporal insula (r = -0.39, p ≤ 0.01) but not in any of the frontal regions. The decrease in DA D2 receptor availability was 6.6{\%} per decade in caudate, 8.2{\%} in putamen, 7.6{\%} in thalamus and 13{\%} in temporal insula. This study indicates that D2 losses with age are not limited to striatum and involve also thalamic as well as temporal cortical regions.",
keywords = "[C]raclopride, aging, extrastriatal dopamine receptors, positron emission tomography",
author = "Wang, {Gene Jack} and Volkow, {Nora D.} and Fowler, {Joanna S.} and Jean Logan and Ruben Gur and Noelwah Netusil and Robert Hitzemann and Pappas, {Naomi S.}",
year = "1996",
month = "5",
day = "31",
doi = "10.1016/0024-3205(96)00262-7",
language = "English (US)",
volume = "59",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Age associated decrements in dopamine D2 receptors in thalamus and in temporal insula of human subjects

AU - Wang, Gene Jack

AU - Volkow, Nora D.

AU - Fowler, Joanna S.

AU - Logan, Jean

AU - Gur, Ruben

AU - Netusil, Noelwah

AU - Hitzemann, Robert

AU - Pappas, Naomi S.

PY - 1996/5/31

Y1 - 1996/5/31

N2 - This study evaluates the effects of age on DA D2 receptors in extrastriatal regions. DA D2 receptor availability was evaluated in 42 healthy male subjects (mean age 41±16, range 21 - 86 year old) with positron emission tomography (PET) and [11C]raclopride. Estimates of B(max.)/K(d) were obtained using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that in cerebellum. Correlations between age and D2 receptors were significant in putamen (r = -0.58, p ≤ 0.0001), caudate (r = -0.54, p ≤ 0.0002), thalamus (r = -0.33, p ≤ 0.03) and temporal insula (r = -0.39, p ≤ 0.01) but not in any of the frontal regions. The decrease in DA D2 receptor availability was 6.6% per decade in caudate, 8.2% in putamen, 7.6% in thalamus and 13% in temporal insula. This study indicates that D2 losses with age are not limited to striatum and involve also thalamic as well as temporal cortical regions.

AB - This study evaluates the effects of age on DA D2 receptors in extrastriatal regions. DA D2 receptor availability was evaluated in 42 healthy male subjects (mean age 41±16, range 21 - 86 year old) with positron emission tomography (PET) and [11C]raclopride. Estimates of B(max.)/K(d) were obtained using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that in cerebellum. Correlations between age and D2 receptors were significant in putamen (r = -0.58, p ≤ 0.0001), caudate (r = -0.54, p ≤ 0.0002), thalamus (r = -0.33, p ≤ 0.03) and temporal insula (r = -0.39, p ≤ 0.01) but not in any of the frontal regions. The decrease in DA D2 receptor availability was 6.6% per decade in caudate, 8.2% in putamen, 7.6% in thalamus and 13% in temporal insula. This study indicates that D2 losses with age are not limited to striatum and involve also thalamic as well as temporal cortical regions.

KW - [C]raclopride

KW - aging

KW - extrastriatal dopamine receptors

KW - positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=0343371815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0343371815&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(96)00262-7

DO - 10.1016/0024-3205(96)00262-7

M3 - Article

C2 - 8684263

AN - SCOPUS:0343371815

VL - 59

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 1

ER -