AFP gene expression after acute diethylnitrosamine intoxication is not Afr2 regulated

David K. Jin, Eric Anderson, Erin Gilbert, Miriam H. Feuerman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The level of alpha-fetoprotein (AFP) gene expression during liver regeneration in mice is regulated by the Afr2 gene. C3H/HeJ mice express 10-fold higher levels of AFP than C57BL/6J mice. We show that AFP gene expression is not Afr2 regulated after intoxication with the carcinogen diethylnitrosamine (DEN). Peak levels of AFP gene expression of the 2 strains were identical, although reached at different times following treatment. Analysis of the expression of AFP derived transgenes not subject to Afr2 regulation and genetic analyses showed that the difference in timing of peak AFP gene expression after DEN intoxication was independent of Afr2 regulation.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalCancer Letters
Volume220
Issue number2
DOIs
StatePublished - Apr 8 2005
Externally publishedYes

Fingerprint

Diethylnitrosamine
alpha-Fetoproteins
Gene Expression
Liver Regeneration
Inbred C3H Mouse
Transgenes
Inbred C57BL Mouse
Carcinogens
Genes

Keywords

  • Afr2
  • Alpha-fetoprotein
  • Diethylnitrosamine
  • Gene regulation
  • Liver regeneration

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

AFP gene expression after acute diethylnitrosamine intoxication is not Afr2 regulated. / Jin, David K.; Anderson, Eric; Gilbert, Erin; Feuerman, Miriam H.

In: Cancer Letters, Vol. 220, No. 2, 08.04.2005, p. 211-220.

Research output: Contribution to journalArticle

Jin, David K. ; Anderson, Eric ; Gilbert, Erin ; Feuerman, Miriam H. / AFP gene expression after acute diethylnitrosamine intoxication is not Afr2 regulated. In: Cancer Letters. 2005 ; Vol. 220, No. 2. pp. 211-220.
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