AFP gene expression after acute diethylnitrosamine intoxication is not Afr2 regulated

David K. Jin; Eric C. Anderson; Erin Gilbert; Miriam H. Feuerman

doi:10.1016/j.canlet.2004.07.031

AFP gene expression after acute diethylnitrosamine intoxication is not Afr2 regulated

David K. Jin, Eric C. Anderson, Erin Gilbert, Miriam H. Feuerman

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The level of alpha-fetoprotein (AFP) gene expression during liver regeneration in mice is regulated by the Afr2 gene. C3H/HeJ mice express 10-fold higher levels of AFP than C57BL/6J mice. We show that AFP gene expression is not Afr2 regulated after intoxication with the carcinogen diethylnitrosamine (DEN). Peak levels of AFP gene expression of the 2 strains were identical, although reached at different times following treatment. Analysis of the expression of AFP derived transgenes not subject to Afr2 regulation and genetic analyses showed that the difference in timing of peak AFP gene expression after DEN intoxication was independent of Afr2 regulation.

Original language	English (US)
Pages (from-to)	211-220
Number of pages	10
Journal	Cancer Letters
Volume	220
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2004.07.031
State	Published - Apr 8 2005
Externally published	Yes

Keywords

Afr2
Alpha-fetoprotein
Diethylnitrosamine
Gene regulation
Liver regeneration

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2004.07.031

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title = "AFP gene expression after acute diethylnitrosamine intoxication is not Afr2 regulated",

abstract = "The level of alpha-fetoprotein (AFP) gene expression during liver regeneration in mice is regulated by the Afr2 gene. C3H/HeJ mice express 10-fold higher levels of AFP than C57BL/6J mice. We show that AFP gene expression is not Afr2 regulated after intoxication with the carcinogen diethylnitrosamine (DEN). Peak levels of AFP gene expression of the 2 strains were identical, although reached at different times following treatment. Analysis of the expression of AFP derived transgenes not subject to Afr2 regulation and genetic analyses showed that the difference in timing of peak AFP gene expression after DEN intoxication was independent of Afr2 regulation.",

keywords = "Afr2, Alpha-fetoprotein, Diethylnitrosamine, Gene regulation, Liver regeneration",

author = "Jin, {David K.} and Anderson, {Eric C.} and Erin Gilbert and Feuerman, {Miriam H.}",

note = "Funding Information: We thank Kathleen Grice for her technical assistance. This work was supported by USPHS Grant CA72612 from the National Cancer Institute and Grant RPG 9825601MGO from the American Cancer Society.",

year = "2005",

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doi = "10.1016/j.canlet.2004.07.031",

language = "English (US)",

volume = "220",

pages = "211--220",

journal = "Cancer Letters",

issn = "0304-3835",

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number = "2",

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T1 - AFP gene expression after acute diethylnitrosamine intoxication is not Afr2 regulated

AU - Jin, David K.

AU - Anderson, Eric C.

AU - Gilbert, Erin

AU - Feuerman, Miriam H.

N1 - Funding Information: We thank Kathleen Grice for her technical assistance. This work was supported by USPHS Grant CA72612 from the National Cancer Institute and Grant RPG 9825601MGO from the American Cancer Society.

PY - 2005/4/8

Y1 - 2005/4/8

N2 - The level of alpha-fetoprotein (AFP) gene expression during liver regeneration in mice is regulated by the Afr2 gene. C3H/HeJ mice express 10-fold higher levels of AFP than C57BL/6J mice. We show that AFP gene expression is not Afr2 regulated after intoxication with the carcinogen diethylnitrosamine (DEN). Peak levels of AFP gene expression of the 2 strains were identical, although reached at different times following treatment. Analysis of the expression of AFP derived transgenes not subject to Afr2 regulation and genetic analyses showed that the difference in timing of peak AFP gene expression after DEN intoxication was independent of Afr2 regulation.

AB - The level of alpha-fetoprotein (AFP) gene expression during liver regeneration in mice is regulated by the Afr2 gene. C3H/HeJ mice express 10-fold higher levels of AFP than C57BL/6J mice. We show that AFP gene expression is not Afr2 regulated after intoxication with the carcinogen diethylnitrosamine (DEN). Peak levels of AFP gene expression of the 2 strains were identical, although reached at different times following treatment. Analysis of the expression of AFP derived transgenes not subject to Afr2 regulation and genetic analyses showed that the difference in timing of peak AFP gene expression after DEN intoxication was independent of Afr2 regulation.

KW - Afr2

KW - Alpha-fetoprotein

KW - Diethylnitrosamine

KW - Gene regulation

KW - Liver regeneration

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JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

AFP gene expression after acute diethylnitrosamine intoxication is not Afr2 regulated

Abstract

Keywords

ASJC Scopus subject areas

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