TY - JOUR
T1 - Affective Behavior in Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant Mice during Long-Term Alcohol Abstinence
AU - Hartmann, Matthew C.
AU - Holbrook, Sarah E.
AU - Haney, Megan M.
AU - Crabbe, John C.
AU - Rosenwasser, Alan M.
N1 - Publisher Copyright:
© 2019 by the Research Society on Alcoholism
PY - 2019/7
Y1 - 2019/7
N2 - Background: While the acute alcohol withdrawal syndrome has been well characterized both in human clinical studies and in experimental animals, much less is known regarding long-term affective disturbances that can sometimes persist during protracted abstinence. Nevertheless, since relapse often occurs long after acute detoxification and may be predicted by persistent affective disruption, a better understanding of the long-term behavioral consequences of prior alcohol dependence may lead to improved strategies for relapse prevention. Methods: Male and female Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant mice from the second selection replicate (WSP-2, WSR-2) were exposed to a 10-day chronic-intermittent ethanol vapor protocol (CIE) or plain air and then tested repeatedly on the sucrose preference test (SPT), marble burying test (MBT), and the light–dark box test (LDT) over 7 weeks of (forced) abstinence. Results: While WSP and WSR mice differed significantly on tests of anxiety-like behavior (LDT, MBT), we found little evidence for long-term affective disruption following CIE in either line. The major exception was in the LDT, in that WSP but not WSR mice displayed longer latencies to enter the light compartment following CIE relative to air-controls. Conclusions: Selective breeding for acute withdrawal severity has resulted in differences in anxiety-like behavior between WSP and WSR mice. In contrast, however, genes contributing to the severity of acute withdrawal convulsions appear to have little overlap with those predisposing to affective disruption during long-term abstinence.
AB - Background: While the acute alcohol withdrawal syndrome has been well characterized both in human clinical studies and in experimental animals, much less is known regarding long-term affective disturbances that can sometimes persist during protracted abstinence. Nevertheless, since relapse often occurs long after acute detoxification and may be predicted by persistent affective disruption, a better understanding of the long-term behavioral consequences of prior alcohol dependence may lead to improved strategies for relapse prevention. Methods: Male and female Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant mice from the second selection replicate (WSP-2, WSR-2) were exposed to a 10-day chronic-intermittent ethanol vapor protocol (CIE) or plain air and then tested repeatedly on the sucrose preference test (SPT), marble burying test (MBT), and the light–dark box test (LDT) over 7 weeks of (forced) abstinence. Results: While WSP and WSR mice differed significantly on tests of anxiety-like behavior (LDT, MBT), we found little evidence for long-term affective disruption following CIE in either line. The major exception was in the LDT, in that WSP but not WSR mice displayed longer latencies to enter the light compartment following CIE relative to air-controls. Conclusions: Selective breeding for acute withdrawal severity has resulted in differences in anxiety-like behavior between WSP and WSR mice. In contrast, however, genes contributing to the severity of acute withdrawal convulsions appear to have little overlap with those predisposing to affective disruption during long-term abstinence.
KW - Affective Behavior
KW - Chronic-Intermittent Ethanol
KW - Protracted Abstinence
KW - Withdrawal Seizure–Prone
KW - Withdrawal Seizure–Resistant
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U2 - 10.1111/acer.14074
DO - 10.1111/acer.14074
M3 - Article
C2 - 31046129
AN - SCOPUS:85066154021
SN - 0145-6008
VL - 43
SP - 1478
EP - 1485
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
IS - 7
ER -