Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption

Orfeu M. Buxton, Sean W. Cain, Shawn P. O'Connor, James H. Porter, Jeanne F. Duffy, Wei Wang, Charles A. Czeisler, Steven A. Shea

Research output: Contribution to journalArticle

401 Scopus citations

Abstract

Epidemiological studies link short sleep duration and circadian disruption with higher risk of metabolic syndrome and diabetes. We tested the hypotheses that prolonged sleep restriction with concurrent circadian disruption, as can occur in people performing shift work, impairs glucose regulation and metabolism. Healthy adults spent >5 weeks under controlled laboratory conditions in which they experienced an initial baseline segment of optimal sleep, 3 weeks of sleep restriction (5.6 hours of sleep per 24 hours) combined with circadian disruption (recurring 28-hour "days"), followed by 9 days of recovery sleep with circadian re-entrainment. Exposure to prolonged sleep restriction with concurrent circadian disruption, with measurements taken at the same circadian phase, decreased the participants' resting metabolic rate and increased plasma glucose concentrations after a meal, an effect resulting from inadequate pancreatic insulin secretion. These parameters normalized during the 9 days of recovery sleep and stable circadian re-entrainment. Thus, in humans, prolonged sleep restriction with concurrent circadian disruption alters metabolism and could increase the risk of obesity and diabetes.

Original languageEnglish (US)
Article number129ra43
JournalScience translational medicine
Volume4
Issue number129
DOIs
StatePublished - Apr 11 2012

ASJC Scopus subject areas

  • Medicine(all)

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    Buxton, O. M., Cain, S. W., O'Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012). Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Science translational medicine, 4(129), [129ra43]. https://doi.org/10.1126/scitranslmed.3003200