Advances in the understanding of human soft tissue sarcomas

Molecular biology and therapeutic strategies (Review)

Kresimira Milas, Dihua Yu, Raphael E. Pollock

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Soft tissue sarcomas comprise a group of exceedingly rare and histologically diverse malignancies. A multidisciplinary approach utilizing surgery, radiation therapy, and chemotherapy has evolved to address the challenge of effective treatment. Pertinent to this clinical goal are efforts to understand the molecular mechanisms underlying the etiology, proliferation, and metastatic phenotype of these tumors. This review describes the specific research efforts of our laboratory, which focus on the role of tumor suppressor genes and angiogenic factors as drivers of malignant behavior in soft-tissue sarcomas. By enlarging our knowledge of basic sarcoma tumor biology, it may be possible to identify important molecular mechanisms that can guide the design of future molecularly based therapies for this disease.

Original languageEnglish (US)
Pages (from-to)1275-1279
Number of pages5
JournalOncology Reports
Volume5
Issue number5
StatePublished - 1998
Externally publishedYes

Fingerprint

Sarcoma
Molecular Biology
Neoplasms
Angiogenesis Inducing Agents
Tumor Suppressor Genes
Radiotherapy
Therapeutics
Phenotype
Drug Therapy
Research

Keywords

  • Gene therapy
  • p53
  • Sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Advances in the understanding of human soft tissue sarcomas : Molecular biology and therapeutic strategies (Review). / Milas, Kresimira; Yu, Dihua; Pollock, Raphael E.

In: Oncology Reports, Vol. 5, No. 5, 1998, p. 1275-1279.

Research output: Contribution to journalArticle

Milas, Kresimira ; Yu, Dihua ; Pollock, Raphael E. / Advances in the understanding of human soft tissue sarcomas : Molecular biology and therapeutic strategies (Review). In: Oncology Reports. 1998 ; Vol. 5, No. 5. pp. 1275-1279.
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