Abstract
Purpose of review Central nervous system tumors represent the most common solid tumors in children and are a leading cause of cancer-related fatalities in this age group. Here, we provide an update on insights gained through molecular profiling of the most common malignant childhood brain tumors. Recent findings Genomic profiling studies of medulloblastoma, ependymoma, and diffuse intrinsic pontine glioma (diffuse midline glioma, with H3-K27M mutation), have refined, if not redefined, the diagnostic classification and therapeutic stratification of patients with these tumors. They detail the substantial genetic heterogeneity across each disease type and, importantly, link genotypic information to clinical course. The most aggressive, treatment-resistant (and also treatment-sensitive) forms within each disease entity are identified, and their potentially actionable targets. Summary Molecularly based classification of pediatric brain tumors provides a critical framework for the more precise stratification and treatment of children with brain tumors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 34-39 |
| Number of pages | 6 |
| Journal | Current Opinion in Pediatrics |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2016 |
| Externally published | Yes |
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Keywords
- brain tumor
- diffuse intrinsic pontine glioma
- ependymoma
- glioblastoma
- medulloblastoma
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Advances in the biology and treatment of pediatric central nervous system tumors. / Vitanza, Nicholas A.; Cho, Yoon-Jae.
In: Current Opinion in Pediatrics, Vol. 28, No. 1, 01.02.2016, p. 34-39.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Advances in the biology and treatment of pediatric central nervous system tumors
AU - Vitanza, Nicholas A.
AU - Cho, Yoon-Jae
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Purpose of review Central nervous system tumors represent the most common solid tumors in children and are a leading cause of cancer-related fatalities in this age group. Here, we provide an update on insights gained through molecular profiling of the most common malignant childhood brain tumors. Recent findings Genomic profiling studies of medulloblastoma, ependymoma, and diffuse intrinsic pontine glioma (diffuse midline glioma, with H3-K27M mutation), have refined, if not redefined, the diagnostic classification and therapeutic stratification of patients with these tumors. They detail the substantial genetic heterogeneity across each disease type and, importantly, link genotypic information to clinical course. The most aggressive, treatment-resistant (and also treatment-sensitive) forms within each disease entity are identified, and their potentially actionable targets. Summary Molecularly based classification of pediatric brain tumors provides a critical framework for the more precise stratification and treatment of children with brain tumors.
AB - Purpose of review Central nervous system tumors represent the most common solid tumors in children and are a leading cause of cancer-related fatalities in this age group. Here, we provide an update on insights gained through molecular profiling of the most common malignant childhood brain tumors. Recent findings Genomic profiling studies of medulloblastoma, ependymoma, and diffuse intrinsic pontine glioma (diffuse midline glioma, with H3-K27M mutation), have refined, if not redefined, the diagnostic classification and therapeutic stratification of patients with these tumors. They detail the substantial genetic heterogeneity across each disease type and, importantly, link genotypic information to clinical course. The most aggressive, treatment-resistant (and also treatment-sensitive) forms within each disease entity are identified, and their potentially actionable targets. Summary Molecularly based classification of pediatric brain tumors provides a critical framework for the more precise stratification and treatment of children with brain tumors.
KW - brain tumor
KW - diffuse intrinsic pontine glioma
KW - ependymoma
KW - glioblastoma
KW - medulloblastoma
UR - http://www.scopus.com/inward/record.url?scp=84954026041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954026041&partnerID=8YFLogxK
U2 - 10.1097/MOP.0000000000000309
DO - 10.1097/MOP.0000000000000309
M3 - Review article
C2 - 26709691
AN - SCOPUS:84954026041
VL - 28
SP - 34
EP - 39
JO - Current Opinion in Pediatrics
JF - Current Opinion in Pediatrics
SN - 1040-8703
IS - 1
ER -