Advances, challenges, and opportunities in extracellular RNA biology: Insights from the NIH exRNA Strategic Workshop

Kang Li; Rodosthenis S. Rodosthenous; Fatah Kashanchi; Thomas Gingeras; Stephen J. Gould; Lillian S. Kuo; Peter Kurre; Hakho Lee; Joshua N. Leonard; Huiping Liu; Tania B. Lombo; Stefan Momma; John P. Nolan; Margaret J. Ochocinska; D. Michiel Pegtel; Yoel Sadovsky; Francisco Sánchez-Madrid; Kayla M. Valdes; Kasey C. Vickers; Alissa M. Weaver; Kenneth W. Witwer; Yong Zeng; Saumya Das; Robert L. Raffai; T. Kevin Howcroft

doi:10.1172/jci.insight.98942

Advances, challenges, and opportunities in extracellular RNA biology: Insights from the NIH exRNA Strategic Workshop

Kang Li, Rodosthenis S. Rodosthenous, Fatah Kashanchi, Thomas Gingeras, Stephen J. Gould, Lillian S. Kuo, Peter Kurre, Hakho Lee, Joshua N. Leonard, Huiping Liu, Tania B. Lombo, Stefan Momma, John P. Nolan, Margaret J. Ochocinska, D. Michiel Pegtel, Yoel Sadovsky, Francisco Sánchez-Madrid, Kayla M. Valdes, Kasey C. Vickers, Alissa M. WeaverKenneth W. Witwer, Yong Zeng, Saumya Das, Robert L. Raffai, T. Kevin Howcroft

Oregon Stem Cell Center

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

Extracellular RNA (exRNA) has emerged as an important transducer of intercellular communication. Advancing exRNA research promises to revolutionize biology and transform clinical practice. Recent efforts have led to cutting-edge research and expanded knowledge of this new paradigm in cell-to-cell crosstalk; however, gaps in our understanding of EV heterogeneity and exRNA diversity pose significant challenges for continued development of exRNA diagnostics and therapeutics. To unravel this complexity, the NIH convened expert teams to discuss the current state of the science, define the significant bottlenecks, and brainstorm potential solutions across the entire exRNA research field. The NIH Strategic Workshop on Extracellular RNA Transport helped identify mechanistic and clinical research opportunities for exRNA biology and provided recommendations on high priority areas of research that will advance the exRNA field.

Original language	English (US)
Article number	e98942
Journal	JCI Insight
Volume	3
Issue number	7
DOIs	https://doi.org/10.1172/jci.insight.98942
State	Published - Apr 5 2018

ASJC Scopus subject areas

General Medicine

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10.1172/jci.insight.98942

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Li, K., Rodosthenous, R. S., Kashanchi, F., Gingeras, T., Gould, S. J., Kuo, L. S., Kurre, P., Lee, H., Leonard, J. N., Liu, H., Lombo, T. B., Momma, S., Nolan, J. P., Ochocinska, M. J., Pegtel, D. M., Sadovsky, Y., Sánchez-Madrid, F., Valdes, K. M., Vickers, K. C., ... Howcroft, T. K. (2018). Advances, challenges, and opportunities in extracellular RNA biology: Insights from the NIH exRNA Strategic Workshop. JCI Insight, 3(7), Article e98942. https://doi.org/10.1172/jci.insight.98942

Li, K, Rodosthenous, RS, Kashanchi, F, Gingeras, T, Gould, SJ, Kuo, LS, Kurre, P, Lee, H, Leonard, JN, Liu, H, Lombo, TB, Momma, S, Nolan, JP, Ochocinska, MJ, Pegtel, DM, Sadovsky, Y, Sánchez-Madrid, F, Valdes, KM, Vickers, KC, Weaver, AM, Witwer, KW, Zeng, Y, Das, S, Raffai, RL & Howcroft, TK 2018, 'Advances, challenges, and opportunities in extracellular RNA biology: Insights from the NIH exRNA Strategic Workshop', JCI Insight, vol. 3, no. 7, e98942. https://doi.org/10.1172/jci.insight.98942

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abstract = "Extracellular RNA (exRNA) has emerged as an important transducer of intercellular communication. Advancing exRNA research promises to revolutionize biology and transform clinical practice. Recent efforts have led to cutting-edge research and expanded knowledge of this new paradigm in cell-to-cell crosstalk; however, gaps in our understanding of EV heterogeneity and exRNA diversity pose significant challenges for continued development of exRNA diagnostics and therapeutics. To unravel this complexity, the NIH convened expert teams to discuss the current state of the science, define the significant bottlenecks, and brainstorm potential solutions across the entire exRNA research field. The NIH Strategic Workshop on Extracellular RNA Transport helped identify mechanistic and clinical research opportunities for exRNA biology and provided recommendations on high priority areas of research that will advance the exRNA field.",

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AU - Li, Kang

AU - Rodosthenous, Rodosthenis S.

AU - Kashanchi, Fatah

AU - Gingeras, Thomas

AU - Gould, Stephen J.

AU - Kuo, Lillian S.

AU - Kurre, Peter

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AU - Leonard, Joshua N.

AU - Liu, Huiping

AU - Lombo, Tania B.

AU - Momma, Stefan

AU - Nolan, John P.

AU - Ochocinska, Margaret J.

AU - Pegtel, D. Michiel

AU - Sadovsky, Yoel

AU - Sánchez-Madrid, Francisco

AU - Valdes, Kayla M.

AU - Vickers, Kasey C.

AU - Weaver, Alissa M.

AU - Witwer, Kenneth W.

AU - Zeng, Yong

AU - Das, Saumya

AU - Raffai, Robert L.

AU - Howcroft, T. Kevin

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AB - Extracellular RNA (exRNA) has emerged as an important transducer of intercellular communication. Advancing exRNA research promises to revolutionize biology and transform clinical practice. Recent efforts have led to cutting-edge research and expanded knowledge of this new paradigm in cell-to-cell crosstalk; however, gaps in our understanding of EV heterogeneity and exRNA diversity pose significant challenges for continued development of exRNA diagnostics and therapeutics. To unravel this complexity, the NIH convened expert teams to discuss the current state of the science, define the significant bottlenecks, and brainstorm potential solutions across the entire exRNA research field. The NIH Strategic Workshop on Extracellular RNA Transport helped identify mechanistic and clinical research opportunities for exRNA biology and provided recommendations on high priority areas of research that will advance the exRNA field.

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Advances, challenges, and opportunities in extracellular RNA biology: Insights from the NIH exRNA Strategic Workshop

Abstract

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