Advanced proximal colon cancer: Paucity of distal lesions validates screening colonoscopy

C. J. Gannon, D. L. Malone, R. E. Royal, Martin Schreiber, B. L. Bass, L. M. Napolitano

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Two recent studies have documented that sigmoidoscopy as a screening tool for colorectal cancers may miss advanced proximal colonic neoplasms. The purpose of this study was to assess the prevalence of distal synchronous lesions in patients with proximal colon cancer. We sought to determine if screening sigmoidoscopy would have missed these proximal colon cancers. Methods: Data were collected on all patients (n = 305) diagnosed with colorectal cancer over a 6-year period. Patients were stratified by age, sex, tumor location, presenting complaint, AJCC stage, and TNM classification. The colonoscopy results of patients diagnosed with proximal colon cancer were analyzed to determine the incidence of synchronous distal colon lesions. Results: Proximal colon cancer was diagnosed in 88 patients (29%). Of those studied, 45 (54%) did not have synchronous distal lesions detected by colonoscopy. The patients with proximal colon cancer were elderly (mean age 67), had advanced tumor size [59 patients (67%) T3/ T4], and had advanced AJCC stages [37 patients (42%) stage III/IV]. Nearly all patients [84 (95%)] with proximal colon cancer were symptomatic. Conclusion: In this study, the majority of patients with proximal colon cancer did not have a synchronous lesion in the distal colon. Current screening methods for colon cancer based on sigmoidoscopy would not have identified these proximal lesions. These findings support the incorporation of screening colonoscopy in protocols designed to identify early colon cancer.

Original languageEnglish (US)
Pages (from-to)446-449
Number of pages4
JournalSurgical Endoscopy and Other Interventional Techniques
Volume16
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Colonoscopy
Colonic Neoplasms
Sigmoidoscopy
Colorectal Neoplasms
Colon
Neoplasm Staging
Neoplasms
Incidence

Keywords

  • Colonoscopy
  • Colorectal cancer
  • Proximal colon cancer
  • Screening
  • Sigmoidoscopy

ASJC Scopus subject areas

  • Surgery

Cite this

Advanced proximal colon cancer : Paucity of distal lesions validates screening colonoscopy. / Gannon, C. J.; Malone, D. L.; Royal, R. E.; Schreiber, Martin; Bass, B. L.; Napolitano, L. M.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 16, No. 3, 2002, p. 446-449.

Research output: Contribution to journalArticle

Gannon, C. J. ; Malone, D. L. ; Royal, R. E. ; Schreiber, Martin ; Bass, B. L. ; Napolitano, L. M. / Advanced proximal colon cancer : Paucity of distal lesions validates screening colonoscopy. In: Surgical Endoscopy and Other Interventional Techniques. 2002 ; Vol. 16, No. 3. pp. 446-449.
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abstract = "Background: Two recent studies have documented that sigmoidoscopy as a screening tool for colorectal cancers may miss advanced proximal colonic neoplasms. The purpose of this study was to assess the prevalence of distal synchronous lesions in patients with proximal colon cancer. We sought to determine if screening sigmoidoscopy would have missed these proximal colon cancers. Methods: Data were collected on all patients (n = 305) diagnosed with colorectal cancer over a 6-year period. Patients were stratified by age, sex, tumor location, presenting complaint, AJCC stage, and TNM classification. The colonoscopy results of patients diagnosed with proximal colon cancer were analyzed to determine the incidence of synchronous distal colon lesions. Results: Proximal colon cancer was diagnosed in 88 patients (29{\%}). Of those studied, 45 (54{\%}) did not have synchronous distal lesions detected by colonoscopy. The patients with proximal colon cancer were elderly (mean age 67), had advanced tumor size [59 patients (67{\%}) T3/ T4], and had advanced AJCC stages [37 patients (42{\%}) stage III/IV]. Nearly all patients [84 (95{\%})] with proximal colon cancer were symptomatic. Conclusion: In this study, the majority of patients with proximal colon cancer did not have a synchronous lesion in the distal colon. Current screening methods for colon cancer based on sigmoidoscopy would not have identified these proximal lesions. These findings support the incorporation of screening colonoscopy in protocols designed to identify early colon cancer.",
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