Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline PART I

William T. Lowrance, Rodney H. Breau, Roger Chou, Brian F. Chapin, Tony Crispino, Robert Dreicer, David F. Jarrard, Adam S. Kibel, Todd M. Morgan, Alicia K. Morgans, William K. Oh, Matthew J. Resnick, Anthony L. Zietman, Michael S. Cookson

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


PURPOSE: The summary presented herein represents Part I of the two-part series dedicated to Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline discussing prognostic and treatment recommendations for patients with biochemical recurrence without metastatic disease after exhaustion of local treatment options as well as those with metastatic hormone-sensitive prostate cancer. Please refer to Part II for discussion of the management of castration-resistant disease. MATERIALS AND METHODS: The systematic review utilized to inform this guideline was conducted by an independent methodological consultant. A research librarian conducted searches in Ovid MEDLINE (1998 to January Week 5 2019), Cochrane Central Register of Controlled Trials (through December 2018), and Cochrane Database of Systematic Reviews (2005 through February 6, 2019). An updated search was conducted prior to publication through January 20, 2020. The methodology team supplemented searches of electronic databases with the studies included in the prior AUA review and by reviewing reference lists of relevant articles. RESULTS: The Advanced Prostate Cancer Panel created evidence- and consensus-based guideline statements to aid clinicians in the management of patients with advanced prostate cancer. Such statements are summarized in figure 1[Figure: see text] and detailed herein. CONCLUSIONS: This guideline attempts to improve a clinician's ability to treat patients diagnosed with advanced prostate cancer. Continued research and publication of high-quality evidence from future trials will be essential to improve the level of care for these patients.

Original languageEnglish (US)
Pages (from-to)14-21
Number of pages8
JournalThe Journal of urology
Issue number1
StatePublished - Jan 1 2021


  • androgen antagonists
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology


Dive into the research topics of 'Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline PART I'. Together they form a unique fingerprint.

Cite this