Advanced magnetic resonance imaging of the physical processes in human Glioblastoma

Jayashree Kalpathy-Cramer, Elizabeth R. Gerstner, Kyrre E. Emblem, Ovidiu C. Andronesi, Bruce Rosen

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Themost commonmalignant primary brain tumor, glioblastomamultiforme(GBM) is a devastating disease with a grim prognosis. Patient survival is typically less than two years and fewer than 10% of patients survive more than five years. Magnetic resonance imaging (MRI) can have great utility in the diagnosis, grading, and management of patients withGBMasmany of the physicalmanifestations of the pathologic processes in GBMcan be visualized and quantified using MRI. Newer MRI techniques such as dynamic contrast enhanced and dynamic susceptibility contrastMRI provide functional information about the tumor hemodynamic status. DiffusionMRI can shed light on tumor cellularity and the disruption of white matter tracts in the proximity of tumors.MRspectroscopy can be used to study newtumor tissuemarkers such as IDHmutations.MRI is helping to noninvasively explore the link between the molecular basis of gliomas and the imaging characteristics of their physical processes. We, here, review several approaches toMR-based imaging and discuss the potential for these techniques to quantify the physical processes in glioblastoma, including tumor cellularity and vascularity, metabolite expression, and patterns of tumor growth and recurrence. We conclude with challenges and opportunities for further research in applying physical principles to better understand the biologic process in this deadly disease.

Original languageEnglish (US)
Pages (from-to)4622-4637
Number of pages16
JournalCancer Research
Volume74
Issue number17
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

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Physical Phenomena
Glioblastoma
Magnetic Resonance Imaging
Neoplasms
Pathologic Processes
Brain Neoplasms
Glioma
Hemodynamics
Recurrence
Survival
Growth
Research

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Kalpathy-Cramer, J., Gerstner, E. R., Emblem, K. E., Andronesi, O. C., & Rosen, B. (2014). Advanced magnetic resonance imaging of the physical processes in human Glioblastoma. Cancer Research, 74(17), 4622-4637. https://doi.org/10.1158/0008-5472.CAN-14-0383

Advanced magnetic resonance imaging of the physical processes in human Glioblastoma. / Kalpathy-Cramer, Jayashree; Gerstner, Elizabeth R.; Emblem, Kyrre E.; Andronesi, Ovidiu C.; Rosen, Bruce.

In: Cancer Research, Vol. 74, No. 17, 01.09.2014, p. 4622-4637.

Research output: Contribution to journalArticle

Kalpathy-Cramer, J, Gerstner, ER, Emblem, KE, Andronesi, OC & Rosen, B 2014, 'Advanced magnetic resonance imaging of the physical processes in human Glioblastoma', Cancer Research, vol. 74, no. 17, pp. 4622-4637. https://doi.org/10.1158/0008-5472.CAN-14-0383
Kalpathy-Cramer J, Gerstner ER, Emblem KE, Andronesi OC, Rosen B. Advanced magnetic resonance imaging of the physical processes in human Glioblastoma. Cancer Research. 2014 Sep 1;74(17):4622-4637. https://doi.org/10.1158/0008-5472.CAN-14-0383
Kalpathy-Cramer, Jayashree ; Gerstner, Elizabeth R. ; Emblem, Kyrre E. ; Andronesi, Ovidiu C. ; Rosen, Bruce. / Advanced magnetic resonance imaging of the physical processes in human Glioblastoma. In: Cancer Research. 2014 ; Vol. 74, No. 17. pp. 4622-4637.
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